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Head of Group
Director of Corporate Program
His main research interests are ligand- and structure-based drug design with focus on transmembrane transport proteins, prediction of on- and off-kinetics, as well as semantic data integration.
Publications
Showing entries 6 - 10 out of 331
Bloothooft, M, Huang, J, Hamze, M, Houtman, MJC, de Boer, TP, van Hasselt, PM, Ecker, GF, Porcher, C, Medina, I & van der Heyden, MAG 2025, 'Exploring the Cell Biological and Functional Effects of the First Disease Associated KCC1 Genetic Variant', Journal of Cellular Physiology, vol. 240, no. 12, e70124. https://doi.org/10.1002/jcp.70124
Vlasveld, M, van den Berk, L, Piñero, J, Helmke, PS, Ecker, GF, van Rossom, R, Schmidt, BZ, Verfaillie, C, Tassis, K, Callegaro, G, Bouwman, P & van de Water, B 2025, 'A broad kinase inhibitor library live cell imaging screen using liver, kidney and cardiac hiPSC-ICAM1-eGFP reporter lineages identifies liabilities for TNFα pathway modulation', Archives of Toxicology, vol. 100, no. 2, pp. 585-601. https://doi.org/10.1007/s00204-025-04226-6
Helmke, PS & Ecker, GF 2025, 'Refining Drug-Induced Cholestasis Prediction: An Explainable Consensus Model Integrating Chemical and Biological Fingerprints', Journal of Chemical Information and Modeling, vol. 65, no. 11, pp. 5301-5316. https://doi.org/10.1021/acs.jcim.4c02363
Goldmann, U, Wiedmer, T, Garofoli, A, Sedlyarov, V, Bichler, M, Haladik, B, Wolf, G, Christodoulaki, E, Ingles-Prieto, A, Ferrada, E, Frommelt, F, Teoh, ST, Leippe, P, Onea, G, Pfeifer, M, Kohlbrenner, M, Chang, L, Selzer, P, Reinhardt, J, Digles, D, Ecker, GF, Osthushenrich, T, MacNamara, A, Malarstig, A, Hepworth, D & Superti-Furga, G 2025, 'Data- and knowledge-derived functional landscape of human solute carriers', Molecular Systems Biology, vol. 21, no. 6, 33, pp. 599-631. https://doi.org/10.1038/s44320-025-00108-2
Mazoudji, A & Ecker, GF 2025, 'Docking-Based Classification of SGLT2 Inhibitors', Molecules (Basel, Switzerland), vol. 30, no. 10, 2179. https://doi.org/10.3390/molecules30102179
Projects
Molecular Drug Targets
Hering, S. (Project Lead), Ecker, G. (Co-Lead), Maulide, N. (Co-Lead), Weinzinger, A. (Co-Lead) & Gonzalez Herrero, L. (Co-Lead)
1/12/10 → 31/12/22
Project: Research funding