Senior scientist
Melanie has gained a deep insight into molecular dynamics simulations and docking methods during her doctoral studies. Currently she is using these techniques to study the human P-glycoprotein by investigating the kinetics as part of the K4DD project.
Superti-Furga G, Lackner D, Wiedmer T, Ingles-Prieto A, RESOLUTE consortium, Steppan C. The RESOLUTE consortium: unlocking SLC transporters for drug discovery. Nature Reviews. Drug Discovery. 2020 Apr 7;19:429-430. doi.org/10.1038/d41573-020-00056-6
Jain S, Grandits M, Ecker GF. Interspecies comparison of putative ligand binding sites of human, rat and mouse P-glycoprotein. European Journal of Pharmaceutical Sciences. 2018 Sep 15;122:134-143. doi.org/10.1016/j.ejps.2018.06.022
Ecker G, Knasmueller B, Neckam B, Grandits M, Dangl A. ToxPHACTS - Data driven decision support for toxicologists. American Chemical Society. Abstracts of Papers (at the National Meeting). 2018 Aug 19;256.