A Structure-Based View on ABC-Transporter Linked to Multidrug Resistance

Author(s)
Jiahui Huang, Gerhard Ecker
Abstract

The discovery of the first ATP-binding cassette (ABC) transporter, whose overexpression in cancer cells is responsible for exporting anticancer drugs out of tumor cells, initiated enormous efforts to overcome tumor cell multidrug resistance (MDR) by inhibition of ABC-transporter. Because of its many physiological functions, diverse studies have been conducted on the mechanism, function and regulation of this important group of transmembrane transport proteins. In this review, we will focus on the structural aspects of this transporter superfamily. Since the resolution revolution of electron microscope, experimentally solved structures increased rapidly. A summary of the structures available and an overview of recent structure-based studies are provided. More specifically, the artificial intelligence (AI)-based predictions from AlphaFold-2 will be discussed.

Organisation(s)
Department of Pharmaceutical Sciences
Journal
Molecules
Volume
28
Pages
494
ISSN
1420-3049
DOI
https://doi.org/10.3390/molecules28020495
Publication date
01-2023
Peer reviewed
Yes
Austrian Fields of Science 2012
301207 Pharmaceutical chemistry
Keywords
ASJC Scopus subject areas
Drug Discovery, Analytical Chemistry, Chemistry (miscellaneous), Molecular Medicine, Physical and Theoretical Chemistry, Pharmaceutical Science, Organic Chemistry
Portal url
https://ucrisportal.univie.ac.at/en/publications/a-structurebased-view-on-abctransporter-linked-to-multidrug-resistance(6688b54f-dcd1-4fcc-92ea-4d4b6b03d7f5).html