PhD Student
Karin studied pharmacy at the University of Vienna and is now a PhD student of the Pharmacoinformatics Research Group. During her master thesis she focused on the elucidation of crucial interactions describing the molecular initiating event (MIE) of neonicotinoid pesticides on human nicotinic acetylcholine receptors. She now continues to work on a structure-based view on MIEs of toxicologically relevant target proteins for her PhD thesis and is involved in the RISK-HUNT3R project. The general aim of the project is to incorporate in silico and in vitro tools as new approach methods in the field of regulatory risk assessment.
Publications
Showing entries 1 - 5 out of 5
Grillberger K, Magel V, Leist M, Ecker GF. Leveraging Consensus Docking Approaches for Human Mitochondrial Complexes I and III. Chemical Research in Toxicology. 2026 Jan 19;39(1):79-94. Epub 2025 Dec 30. doi: 10.1021/acs.chemrestox.5c00348
Magel V, Blum J, Dolde X, Leisner H, Grillberger K, Khalidi H et al. Inhibition of Neural Crest Cell Migration by Strobilurin Fungicides and Other Mitochondrial Toxicants. Cells. 2024 Dec;13(24):2057. doi: 10.3390/cells13242057
Grillberger K, Cöllen E, Trivisani CI, Blum J, Leist M, Ecker G. Structural Insights into Neonicotinoids and N-Unsubstituted Metabolites on Human nAChRs by Molecular Docking, Dynamics Simulations, and Calcium Imaging. International Journal of Molecular Sciences. 2023 Aug 24;24(17):13170. doi: 10.3390/ijms241713170
Loser D, Grillberger K, Hinojosa MG, Blum J, Haufe Y, Danker T et al. Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling. Archives of Toxicology. 2021 Oct 10;95(12):3695-3716. doi: 10.1007/s00204-021-03168-z
Loser D, Hinojosa MG, Blum J, Schaefer J, Brüll M, Johansson Y et al. Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons. Archives of Toxicology. 2021 Jun;95(6):2081-2107. doi: 10.1007/s00204-021-03031-1