Univ.-Prof. Mag. Dr. Gerhard Ecker
T: +43-1-4277-55110
M: +43-664-60277-55110

Consultation hours: Mon 13:00 - 14:00, 2E405 or online, registration per E-mail necessary

Van der Stel, W, Carta, G, Eakins, J, Delp, J, Suciu, I, Forsby, A, Cediel-Ulloa, A, Attoff, K, Troger, F, Kamp, H, Gardner, I, Zdrazil, B, Moné, MJ, Ecker, GF, Pastor, M, Gómez-Tamayo, JC, White, A, Danen, EHJ, Leist, M, Walker, P, Jennings, P, Hougaard Bennekou, S & Van de Water, B 2021, 'New approach methods supporting read-across: Two neurotoxicity AOP-based IATA case studies', Altex. https://doi.org/10.14573/altex.2103051

Loser, D, Hinojosa, MG, Blum, J, Schaefer, J, Brüll, M, Johansson, Y, Suciu, I, Grillberger, K, Danker, T, Möller, C, Gardner, I, Ecker, GF, Bennekou, SH, Forsby, A, Kraushaar, U & Leist, M 2021, 'Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons', Archives of Toxicology, vol. 95, no. 6, pp. 2081-2107. https://doi.org/10.1007/s00204-021-03031-1

Niello, M, Cintulová, D, Raithmayr, P, Holy, M, Jäntsch, K, Colas, C, Ecker, GF, Sitte, HH & Mihovilovic, MD 2021, 'Effects of Hydroxylated Mephedrone Metabolites on Monoamine Transporter Activity in vitro', Frontiers in Pharmacology, vol. 12, 654061. https://doi.org/10.3389/fphar.2021.654061


Cosco, J, Scalise, M, Colas, C, Galluccio, M, Martini, R, Rovella, F, Mazza, T, Ecker, GF & Indiveri, C 2020, 'ATP modulates SLC7A5 (LAT1) synergistically with cholesterol', Scientific Reports, vol. 10, no. 1, pp. 16738. https://doi.org/10.1038/s41598-020-73757-y






Superti-Furga, G, Lackner, D, Wiedmer, T, Ingles-Prieto, A, RESOLUTE consortium & Steppan, C 2020, 'The RESOLUTE consortium: unlocking SLC transporters for drug discovery', Nature Reviews. Drug Discovery, vol. 19, pp. 429-430. https://doi.org/10.1038/d41573-020-00056-6



Girardi, E, César-Razquin, A, Lindinger, S, Papakostas, K, Konecka, J, Hemmerich, J, Kickinger, S, Kartnig, F, Gürtl, B, Klavins, K, Sedlyarov, V, Ingles-Prieto, A, Fiume, G, Koren, A, Lardeau, C-H, Kumaran Kandasamy, R, Kubicek, S, Ecker, GF & Superti-Furga, G 2020, 'A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs', Nature Chemical Biology, vol. 16, pp. 469–478. https://doi.org/10.1038/s41589-020-0483-3



Niello, M, Cintulova, D, Hellsberg, E, Jäntsch, K, Holy, M, Ayatollahi, LH, Cozzi, NV, Freissmuth, M, Sandtner, W, Ecker, GF, Mihovilovic, MD & Sitte, HH 2019, 'para-Trifluoromethyl-methcathinone is an allosteric modulator of the serotonin transporter', Neuropharmacology, vol. 161, 107615. https://doi.org/10.1016/j.neuropharm.2019.04.021



Eichsteininger, J, Kirisits, K, Smöch, C, Stadlbauer, C, Nguyen, CH, Jäger, W, Özmen, A, Ecker, G, Krupitza, G & Krenn, L 2019, 'Structural insight into the in vitro anti-intravasative properties of flavonoids', Scientia Pharmaceutica, vol. 87, no. 3, 23. https://doi.org/10.3390/scipharm87030023

Arzneistoffentwicklung in Zeiten personalisierter Medizin

Gerhard Ecker (Speaker)

19 Jun 2021

Activity: Talks and presentationsTalk or oral contributionScience to Science


In silico Toxicology - from prediction of transporter interaction profiles to toxicological read across and beyond

Gerhard Ecker (Speaker)

20 May 2019

Activity: Talks and presentationsTalk or oral contributionScience to Science


The OMICS approach - the buzz that makes the world go round

Gerhard Ecker (Speaker)

27 Mar 2019

Activity: Talks and presentationsTalk or oral contributionScience to Science


Upsampling of Molecules to create datasets large enough for Deep learning in toxicity prediction

Jennifer Hemmerich (Speaker), Ece Asilar (Contributor) & Gerhard Ecker (Contributor)

12 Nov 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


DEEPHUNT: HEPATOTOXICITY USING NEURAL NETWORKS.

Ece Asilar (Speaker), Jennifer Hemmerich (Contributor) & Gerhard Ecker (Contributor)

20 Sep 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


Exploring the use of neural networks for prediction of toxicities

Jennifer Hemmerich (Speaker), Ece Asilar (Contributor) & Gerhard Ecker (Contributor)

21 Jul 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


Predicting ligand residence time - it's all about how long you stay

Gerhard Ecker (Speaker)

4 Jul 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


Leveraging integrated life science data – the power of workflows

Gerhard Ecker (Speaker)

19 Mar 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


In silico Toxicology - from prediction of transporter interaction profiles to toxicological read across and beyond

Gerhard Ecker (Invited speaker)

13 Mar 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


Linking open data - from transporter interaction profiles to toxicity prediction

Gerhard Ecker (Invited speaker)

20 Sep 2017

Activity: Talks and presentationsTalk or oral contributionScience to Science


Predicting drug residence time - its all about how long you stay

Gerhard Ecker (Invited speaker)

18 Sep 2017

Activity: Talks and presentationsTalk or oral contributionScience to Science


Open PHACTS - Exploiting semantically integrated life science data for transporter profiling

Gerhard Ecker (Invited speaker)

7 Aug 2017

Activity: Talks and presentationsTalk or oral contributionScience to Science


Leveraging linked open data - from transporter interaction profiling to toxicity prediction and beyond

Gerhard Ecker (Invited speaker)

23 May 2017

Activity: Talks and presentationsTalk or oral contributionScience to Science


Innovative Medicines Initiative - From semantic data integration to risk assessment

Gerhard Ecker (Invited speaker)

5 Apr 2017

Activity: Talks and presentationsTalk or oral contributionScience to Science


Leveraging open data for development of ABC-transporter inhibitors

Gerhard Ecker (Invited speaker)

27 Mar 2017

Activity: Talks and presentationsTalk or oral contributionScience to Science


Leveraging linked open data - from transporter profiling to toxicity prediction and beyond

Gerhard Ecker (Invited speaker)

21 Mar 2017

Activity: Talks and presentationsTalk or oral contributionScience to Science


Leveraging linked open data - from transporter interaction profiling to toxicity prediction and beyond

Gerhard Ecker (Invited speaker)

15 Mar 2017

Activity: Talks and presentationsTalk or oral contributionScience to Science


Exploiting semantically integrated life science data - from transporter profiling to toxicity prediction

Gerhard Ecker (Invited speaker)

9 Feb 2017

Activity: Talks and presentationsTalk or oral contributionScience to Science


The power of open data - linking transporter interaction profiles to in vivo toxicity

Gerhard Ecker (Invited speaker)

3 Feb 2017

Activity: Talks and presentationsTalk or oral contributionScience to Science


Leveraging linked open data - from transporter interaction profiles to toxicity prediction

Gerhard Ecker (Invited speaker)

19 Jan 2017

Activity: Talks and presentationsTalk or oral contributionScience to Science


Open Innovation in the Age of Big Data

Gerhard Ecker (Invited speaker)

17 Nov 2016

Activity: Talks and presentationsTalk or oral contributionOther


Exploiting Linked Open Data - the Power of Workflows

Gerhard Ecker (Invited speaker)

12 Apr 2016

Activity: Talks and presentationsTalk or oral contributionOther


Quantitative structure-kinetics relationships - can we predict on and off-kinetics?

Gerhard Ecker (Invited speaker)

4 Nov 2014

Activity: Talks and presentationsTalk or oral contributionOther


the Open PHACTS Discovery Platform - Semantic data integration in Pharmacoinformatics

Gerhard Ecker (Invited speaker)

26 Sep 2014

Activity: Talks and presentationsTalk or oral contributionOther


It's all about integration - from docking to structure-based classification and prediction of side effects

Gerhard Ecker (Invited speaker)

10 Sep 2014

Activity: Talks and presentationsTalk or oral contributionOther


The Open PHACTS Discovery Platform - Semantic data integration for medicinal chemists

Gerhard Ecker (Invited speaker)

8 Sep 2014

Activity: Talks and presentationsTalk or oral contributionOther


Open PHACTS - the use of open data for in silico models

Gerhard Ecker (Invited speaker)

4 Sep 2014

Activity: Talks and presentationsTalk or oral contributionOther


Exploiting integrated open data in drug discovery

Gerhard Ecker (Invited speaker)

9 May 2014

Activity: Talks and presentationsTalk or oral contributionOther


It's all about integration - From docking poses to structure-based classification and prediction of side effects

Gerhard Ecker (Invited speaker)

25 Apr 2014

Activity: Talks and presentationsTalk or oral contributionOther


Open PHACTS - Building an open pharmacological space

Gerhard Ecker (Invited speaker)

3 Apr 2014

Activity: Talks and presentationsTalk or oral contributionOther


Experimental data guided docking for elucidating the molecular basis of drug-transporter interaction

Gerhard Ecker (Invited speaker)

18 Dec 2013

Activity: Talks and presentationsTalk or oral contributionOther


Experimental data guided docking allows to elucidate the molecular basis of drug-transporter interaction

Gerhard Ecker (Invited speaker)

4 Dec 2013

Activity: Talks and presentationsTalk or oral contributionOther


Arzneistoffdesign am computer - Spielerei oder Wissenschaft

Gerhard Ecker (Speaker)

27 Oct 2013

Activity: Talks and presentationsTalk or oral contributionOther


Computational Drug Design

Gerhard Ecker (Keynote speaker)

24 Jul 2013

Activity: Talks and presentationsTalk or oral contributionOther


Integrated approaches - from docking poses to prediction of side effects

Gerhard Ecker (Keynote speaker)

1 Jul 2013

Activity: Talks and presentationsTalk or oral contributionOther


Exploiting open data - a new era in pharmacoinformatics

Gerhard Ecker (Invited speaker)

22 May 2013

Activity: Talks and presentationsTalk or oral contributionOther


Open PHACTS - a novel platform for integrated data-driven drug discovery

Gerhard Ecker (Invited speaker)

20 Mar 2013

Activity: Talks and presentationsTalk or oral contributionOther


Arzneistoffentwicklung am Computer - Fact or Fiction?

Gerhard Ecker (Invited speaker)

8 Mar 2013

Activity: Talks and presentationsTalk or oral contributionOther


Pharmacoinformatics - from data integration to in silico screening

Gerhard Ecker (Speaker)

1 Mar 2013

Activity: Talks and presentationsTalk or oral contributionOther


The medicinal chemistry of drug transport – knowledge based ligand design.

Gerhard Ecker (Speaker)

28 Nov 2012

Activity: Talks and presentationsTalk or oral contributionOther


Ligand efficiency and lipophilic efficiency – versatile parameters for the design of inhibitors of transmembrane transporters?

Gerhard Ecker (Speaker)

24 Sep 2012

Activity: Talks and presentationsTalk or oral contributionOther


The molecular basis of drug-transporter interaction - science or fiction?

Gerhard Ecker (Speaker)

12 Jul 2012

Activity: Talks and presentationsTalk or oral contributionOther


Arzneistofftransporter und ihre Rolle in der Pharmaforschung

Gerhard Ecker (Speaker)

21 Jun 2012

Activity: Talks and presentationsTalk or oral contributionOther


Drug Transporters – Structure, Function, and Modulation

Gerhard Ecker (Speaker)

21 Mar 2012

Activity: Talks and presentationsTalk or oral contributionOther


Knowledge driven ligand design – ligand-based design meets protein structures

Gerhard Ecker (Speaker)

7 Mar 2012

Activity: Talks and presentationsTalk or oral contributionOther


Ligand- and structure-based approaches for targeting drug transporter

Gerhard Ecker (Invited speaker)

20 Sep 2010

Activity: Talks and presentationsTalk or oral contributionOther


Experimental data guided ligand docking - a versatile approach for elucidating the molecular basis of drug/transporter interactions

Gerhard Ecker (Invited speaker)

3 Sep 2010

Activity: Talks and presentationsTalk or oral contributionOther


Computational drug design - where are we and where to go

Gerhard Ecker (Keynote speaker)

17 Jun 2010

Activity: Talks and presentationsTalk or oral contributionOther


Prediction of ADMET – from rules to networks

Gerhard Ecker (Invited speaker)

24 May 2010

Activity: Talks and presentationsTalk or oral contributionOther


The medicinal chemistry of drug transporters

Gerhard Ecker (Invited speaker)

24 Apr 2010

Activity: Talks and presentationsTalk or oral contributionOther


In silico studies for prediction of substrates and inhibitors of P-glycoprotein.

Gerhard Ecker (Invited speaker)

1 Sep 2009

Activity: Talks and presentationsTalk or oral contributionOther


The medicinal chemistry of P-glycoprotein – ligand- and target-based studies

Gerhard Ecker (Invited speaker)

1 Aug 2009

Activity: Talks and presentationsTalk or oral contributionOther


In silico models for classification of ABC-transporter substrates to improve ADMET profiling

Gerhard Ecker (Contributor)

27 Jun 2009

Activity: Talks and presentationsTalk or oral contributionOther


Pharmacoinformatics – combining experimental pharmaceutical sciences with in silico methods

Gerhard Ecker (Speaker)

9 Jun 2009

Activity: Talks and presentationsTalk or oral contributionOther


Predicting substrate properties for ABC-Transporter - Safety Sciences on the molecular level

Gerhard Ecker (Invited speaker)

7 May 2009

Activity: Talks and presentationsTalk or oral contributionOther


SIBAR descriptors and support vector machines for ABCB1 substrate prediction

Gerhard Ecker (Contributor)

16 Apr 2009

Activity: Talks and presentationsTalk or oral contributionOther


Predicting Ligands of ABC-transporter - a long way to go

Gerhard Ecker (Invited speaker)

13 Mar 2009

Activity: Talks and presentationsTalk or oral contributionOther


Predicting Interaction with ABC-Transporters involved in ADME

Gerhard Ecker (Keynote speaker)

10 Feb 2009

Activity: Talks and presentationsTalk or oral contributionOther


Safety Sciences in silico - Analyse unerwünschter Wirkungen durch molekulare Modellierung

Gerhard Ecker (Keynote speaker)

19 Nov 2008

Activity: Talks and presentationsTalk or oral contributionOther


Optimising ligands for promiscuous targets - a case study for P-glycoprotein inhibitors

Gerhard Ecker (Invited speaker)

20 Oct 2008

Activity: Talks and presentationsTalk or oral contributionOther


Prediction of ligands of promiscuous targets - safety sciences on the molecular level

Gerhard Ecker (Invited speaker)

20 Oct 2008

Activity: Talks and presentationsTalk or oral contributionOther


Optimizing Ligands for Promiscuous Targets - A Case Study for P-glycoprotein Inhibitors

Gerhard Ecker (Invited speaker)

26 Sep 2008

Activity: Talks and presentationsTalk or oral contributionOther


Pharmacoinformatic approaches to target polyspecific proteins

Gerhard Ecker (Invited speaker)

13 Sep 2008

Activity: Talks and presentationsTalk or oral contributionOther


Use your brain - artificial neural networks in drug discovery

Gerhard Ecker (Invited speaker)

12 Sep 2008

Activity: Talks and presentationsTalk or oral contributionOther


EUROPIN - A European Pharmacoinformatics Initative

Gerhard Ecker (Invited speaker)

4 Jul 2008

Activity: Talks and presentationsTalk or oral contributionOther


P-glycoprotein - from inhibitor design to substrate prediction

Gerhard Ecker (Invited speaker)

3 Jul 2008

Activity: Talks and presentationsTalk or oral contributionOther


Prediction of substrate properties for ABC Drug-Transporter: The challenge continues

Gerhard Ecker (Invited speaker)

19 May 2008

Activity: Talks and presentationsTalk or oral contributionOther


Classification models for hERG inhibitors by counter-propagation neural networks

Gerhard Ecker (Contributor)

10 Apr 2008

Activity: Talks and presentationsTalk or oral contributionOther


Pharmacoinformatic approaches to target P-glycoprotein - from inhibitor design to substrate prediction

Gerhard Ecker (Invited speaker)

8 Apr 2008

Activity: Talks and presentationsTalk or oral contributionOther


EUROPIN - A European Pharmacoinformatics Initative

Gerhard Ecker (Invited speaker)

11 Mar 2008

Activity: Talks and presentationsTalk or oral contributionOther


Predicting ligands for P-glycoprotein - safety sciences on the molecular level

Gerhard Ecker (Speaker)

29 Feb 2008

Activity: Talks and presentationsTalk or oral contributionOther


Computermodels for predicting P-glycoprotein substrates - can we guide the lead optimisation process?

Gerhard Ecker (Speaker)

21 Feb 2008

Activity: Talks and presentationsTalk or oral contributionOther


Linking chemical space to biological space - challenges for high-throughput computing

Gerhard Ecker (Speaker)

31 Jan 2008

Activity: Talks and presentationsTalk or oral contributionOther


Use your brain - artificial neural networks in drug design

Gerhard Ecker (Speaker)

7 Dec 2007

Activity: Talks and presentationsTalk or oral contributionOther


Polyspecific proteins - safety sciences on the molecular level

Gerhard Ecker (Speaker)

25 Oct 2007

Activity: Talks and presentationsTalk or oral contributionOther


P-glycoprotein - design of inhibitors and prediction of substrates

Gerhard Ecker (Speaker)

11 Sep 2007

Activity: Talks and presentationsTalk or oral contributionOther


Vortrag auf Kongress: Recent developments in physics of fundamental interactions

Gerhard Ecker (Invited speaker)

5 Sep 2007

Activity: Talks and presentationsTalk or oral contributionOther


Multispecificity of drug transporter - probing inhibitor selectivity for the human drug efflux transporter ABCB1 and ABCG2

Gerhard Ecker (Speaker)

27 Aug 2007

Activity: Talks and presentationsTalk or oral contributionOther


Chemigenomics and Drug Discovery

Gerhard Ecker (Invited speaker)

9 Jul 2007

Activity: Talks and presentationsTalk or oral contributionOther


P-glycoprotein - from target to antitarget

Gerhard Ecker (Speaker)

28 Jun 2007

Activity: Talks and presentationsTalk or oral contributionOther


Predicting ligands for ABC-transporter - structure-based vs ligand-based approaches

Gerhard Ecker (Invited speaker)

25 Jun 2007

Activity: Talks and presentationsTalk or oral contributionOther


Polyspecific proteins - a challenge in pharmacoinformatics

Gerhard Ecker (Speaker)

22 Jun 2007

Activity: Talks and presentationsTalk or oral contributionOther


Comparative Analysis of two Different Classifiers for Predicting P-glycoprotein Substrates

Gerhard Ecker (Contributor)

17 Jun 2007

Activity: Talks and presentationsTalk or oral contributionOther


Machine learning methods for classification and hit identification

Gerhard Ecker (Invited speaker)

3 Jun 2007

Activity: Talks and presentationsTalk or oral contributionOther


Role of structural models of P-glycoprotein - the prediction of actively transported small molecules

Gerhard Ecker (Invited speaker)

14 Apr 2007

Activity: Talks and presentationsTalk or oral contributionOther


Von Penicillin bis Viagra : Arzneistoffentwicklung gestern - heute - morgen

Gerhard Ecker (Speaker)

23 Nov 2006

Activity: Talks and presentationsTalk or oral contributionOther


Von Penicillin bis Viagra : Arzneistoffentwicklung gestern - heute - morgen

Gerhard Ecker (Speaker)

22 Nov 2006

Activity: Talks and presentationsTalk or oral contributionOther


In silico methods for hit identification and prediction of biological activities

Gerhard Ecker (Speaker)

16 Nov 2006

Activity: Talks and presentationsTalk or oral contributionOther


Drug efflux pumps - From target to antitarget

Gerhard Ecker (Invited speaker)

15 Nov 2006

Activity: Talks and presentationsTalk or oral contributionOther


MDR - Multiple Drug Resistance

Gerhard Ecker (Invited speaker)

9 Oct 2006

Activity: Talks and presentationsTalk or oral contributionOther


Pharmacoinformatic approaches to target the molecular basis of polyspecificity

Gerhard Ecker (Invited speaker)

28 Sep 2006

Activity: Talks and presentationsTalk or oral contributionOther


ABC-transporter as antitargets

Gerhard Ecker (Invited speaker)

26 Sep 2006

Activity: Talks and presentationsTalk or oral contributionOther


In silico methods for prediction of P-glycoprotein substrates

Gerhard Ecker (Invited speaker)

30 Aug 2006

Activity: Talks and presentationsTalk or oral contributionOther


Non-linear methods and machine learning in drug discovery

Gerhard Ecker (Invited speaker)

6 Jul 2006

Activity: Talks and presentationsTalk or oral contributionOther


In vitro and in silico models for prediction of P-glycoprotein substrates

Gerhard Ecker (Invited speaker)

27 Jun 2006

Activity: Talks and presentationsTalk or oral contributionOther


A flow based hollow-fiber blood-brain barrier in vitro model with immortalised cell line PBMEC/C1-2

Gerhard Ecker (Contributor)

25 Jun 2006

Activity: Talks and presentationsTalk or oral contributionOther


P-glycoprotein - From target to antitarget

Gerhard Ecker (Invited speaker)

7 Apr 2006

Activity: Talks and presentationsTalk or oral contributionOther


Pharmacoinformatic approaches to target polyspecific proteins

Gerhard Ecker (Invited speaker)

21 Feb 2006

Activity: Talks and presentationsTalk or oral contributionOther


Department of Pharmaceutical Sciences

Althanstraße 14 (UZA II)
1090 Wien
Room: 2E405

T: +43-1-4277-55110
M: +43-664-60277-55110
F: +43-1-4277-855110

gerhard.f.ecker@univie.ac.at