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Head of Group
Director of Corporate Program
His main research interests are ligand- and structure-based drug design with focus on transmembrane transport proteins, prediction of on- and off-kinetics, as well as semantic data integration.
Publications
Showing entries 1 - 5 out of 312
Li, E, Boujeddaine, N, Houtman, MJC, Maas, Sluijter, , Ecker, G, Weinzinger, A, van Ham, W & van der Heyden, M 2024, 'Development of new Kir2.1 channel openers from propafenone analogues', British Journal of Pharmacology. <https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17377>
Digles, D, Ingles-Prieto, A, Dvorak, V, Mocking, TAM, Goldmann, U, Garofoli, A, Homan, EJ, Di Silvio, A, Azzollini, L, Sassone, F, Fogazza, M, Bärenz, F, Pommereau, A, Zuschlag, Y, Ooms, JF, Tranberg-Jensen, J, Hansen, JS, Stanka, J, Sijben, HJ, Batoulis, H, Bender, E, Martini, R, IJzerman, AP, Sauer, DB, Heitman, LH, Manolova, V, Reinhardt, J, Ehrmann, A, Leippe, P, Ecker, GF, Huber, KVM, Licher, T, Scarabottolo, L, Wiedmer, T & Superti-Furga, G 2024, 'Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily', Frontiers in Pharmacology, vol. 15, 1401599. https://doi.org/10.3389/fphar.2024.1401599
Granulo, N, Sosnin, S, Digles, D & Ecker, GF 2024, 'The macrocycle inhibitor landscape of SLC‐transporter', Molecular Informatics, vol. 43, no. 5, e202300287. https://doi.org/10.1002/minf.202300287
Huang, J, Osthushenrich, T, MacNamara, A, Mälarstig, A, Brocchetti, S, Bradberry, S, Scarabottolo, L, Ferrada, E, Sosnin, S, Digles, D, Superti-Furga, G & Ecker, GF 2024, 'ProteoMutaMetrics: machine learning approaches for solute carrier family 6 mutation pathogenicity prediction', Rsc advances, vol. 14, no. 19, 00748, pp. 13083-13094. https://doi.org/10.1039/d4ra00748d
Ferrada, E, Wiedmer, T, Wang, WA, Frommelt, F, Steurer, B, Klimek, C, Lindinger, S, Osthushenrich, T, Garofoli, A, Brocchetti, S, Bradberry, S, Huang, J, MacNamara, A, Scarabottolo, L, Ecker, GF, Malarstig, A & Superti-Furga, G 2024, 'Experimental and Computational Analysis of Newly Identified Pathogenic Mutations in the Creatine Transporter SLC6A8', Journal of Molecular Biology, vol. 436, no. 2, 168383. https://doi.org/10.1016/j.jmb.2023.168383
Activities
Showing entries 91 - 95 out of 202
Ligand based screening tools for identification of insulin receptor activating compounds.
Daniela Digles
,
Verena Dirsch
,
Gerhard Ecker
239th ACS National Meeting
Conference,
Poster presentation
..2010 - ..2010
QSAR, ligand efficiency (LE) and lipophilic efficiency (LipE) studies of a series of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.
Ishrat Jabeen
,
Zahida Parveen
,
Uwe Rinner
,
Peter Chiba
,
Gerhard Ecker
240th American Chemical Society National Meeting & Exposition
Conference,
Poster presentation
..2010 - ..2010
QSAR, ligand efficiency (LE) and lipophilic efficiency (LipE) studies of a series of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.
Ishrat Jabeen
,
Zahida Parveen
,
Uwe Rinner
,
Peter Chiba
,
Gerhard Ecker
3rd SFB35 Symposium 2010
Conference,
Poster presentation
..2010 - ..2010
Stereoselective interaction of benzopyrano[3,4-b][1,4]oxazines with p-glycoprotein.
Ishrat Jabeen
,
Penpun Wetwitayaklung
,
Freya Klepsch
,
Peter Chiba
,
Gerhard Ecker
18th European Symposium on Quantitative Structure-Activity Relationships
Conference,
Poster presentation
..2010 - ..2010
Synthesis and biological evaluation of novel carbocycle-containing combretastatin A-4 analogs
Rita Fürst
,
Christina Nowikow
,
Agnes Berenyi
,
Gerhard Ecker
,
Walther Schmid
,
Istvan Zupko
,
Uwe Rinner
240th American Chemical Society National Meeting & Exposition
Conference,
Poster presentation
..2010 - ..2010