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Head of Group
Director of Corporate Program
His main research interests are ligand- and structure-based drug design with focus on transmembrane transport proteins, prediction of on- and off-kinetics, as well as semantic data integration.
Publications
Showing entries 1 - 5 out of 312
Li, E, Boujeddaine, N, Houtman, MJC, Maas, Sluijter, , Ecker, G, Weinzinger, A, van Ham, W & van der Heyden, M 2024, 'Development of new Kir2.1 channel openers from propafenone analogues', British Journal of Pharmacology. <https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17377>
Digles, D, Ingles-Prieto, A, Dvorak, V, Mocking, TAM, Goldmann, U, Garofoli, A, Homan, EJ, Di Silvio, A, Azzollini, L, Sassone, F, Fogazza, M, Bärenz, F, Pommereau, A, Zuschlag, Y, Ooms, JF, Tranberg-Jensen, J, Hansen, JS, Stanka, J, Sijben, HJ, Batoulis, H, Bender, E, Martini, R, IJzerman, AP, Sauer, DB, Heitman, LH, Manolova, V, Reinhardt, J, Ehrmann, A, Leippe, P, Ecker, GF, Huber, KVM, Licher, T, Scarabottolo, L, Wiedmer, T & Superti-Furga, G 2024, 'Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily', Frontiers in Pharmacology, vol. 15, 1401599. https://doi.org/10.3389/fphar.2024.1401599
Granulo, N, Sosnin, S, Digles, D & Ecker, GF 2024, 'The macrocycle inhibitor landscape of SLC‐transporter', Molecular Informatics, vol. 43, no. 5, e202300287. https://doi.org/10.1002/minf.202300287
Huang, J, Osthushenrich, T, MacNamara, A, Mälarstig, A, Brocchetti, S, Bradberry, S, Scarabottolo, L, Ferrada, E, Sosnin, S, Digles, D, Superti-Furga, G & Ecker, GF 2024, 'ProteoMutaMetrics: machine learning approaches for solute carrier family 6 mutation pathogenicity prediction', Rsc advances, vol. 14, no. 19, 00748, pp. 13083-13094. https://doi.org/10.1039/d4ra00748d
Ferrada, E, Wiedmer, T, Wang, WA, Frommelt, F, Steurer, B, Klimek, C, Lindinger, S, Osthushenrich, T, Garofoli, A, Brocchetti, S, Bradberry, S, Huang, J, MacNamara, A, Scarabottolo, L, Ecker, GF, Malarstig, A & Superti-Furga, G 2024, 'Experimental and Computational Analysis of Newly Identified Pathogenic Mutations in the Creatine Transporter SLC6A8', Journal of Molecular Biology, vol. 436, no. 2, 168383. https://doi.org/10.1016/j.jmb.2023.168383
Activities
Showing entries 86 - 90 out of 202
The medicinal chemistry of drug transporters
Gerhard Ecker
14th Hellenic Symposium on Medicinal Chemistry
Conference,
Talk or oral contribution
24.4.2010 - 24.4.2010
Docking studies of propafenone derivatives into a homology model of the hERG channel in the open state.
Andrea Schiesaro
,
Andreas Windisch
,
Evgeny Timin
,
Steffen Hering
,
Gerhard Ecker
240th American Chemical Society National Meeting & Exposition
Conference,
Poster presentation
..2010 - ..2010
Exhaustive sampling of docking poses reveals possible binding modes of propafenones in p-glycoprotein.
Freya Klepsch
,
Peter Chiba
,
Gerhard Ecker
XXIst International Symposium of Medicinal Chemistry
Conference,
Poster presentation
..2010 - ..2010
Identification of binding modes of benzodiazepine binding site ligands by a combined docking-pharmacophore modeling approach.
Lars Richter
,
Margot Ernst
,
Werner Sieghart
,
Gerhard Ecker
XXIst International Symposium of Medicinal Chemistry
Conference,
Poster presentation
..2010 - ..2010
Interaction of low molecular weight ligands with human P-glycoprotein.
Zahida Parveen
,
Thomas Stockner
,
Edina Csaszar
,
Gerhard Ecker
,
Michael Freissmuth
,
Peter Chiba
3rd SFB35 Symposium 2010
Conference,
Poster presentation
..2010 - ..2010