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Head of Group
Director of Corporate Program
His main research interests are ligand- and structure-based drug design with focus on transmembrane transport proteins, prediction of on- and off-kinetics, as well as semantic data integration.
Publications
Showing entries 1 - 5 out of 312
Li, E, Boujeddaine, N, Houtman, MJC, Maas, Sluijter, , Ecker, G, Weinzinger, A, van Ham, W & van der Heyden, M 2024, 'Development of new Kir2.1 channel openers from propafenone analogues', British Journal of Pharmacology. <https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17377>
Digles, D, Ingles-Prieto, A, Dvorak, V, Mocking, TAM, Goldmann, U, Garofoli, A, Homan, EJ, Di Silvio, A, Azzollini, L, Sassone, F, Fogazza, M, Bärenz, F, Pommereau, A, Zuschlag, Y, Ooms, JF, Tranberg-Jensen, J, Hansen, JS, Stanka, J, Sijben, HJ, Batoulis, H, Bender, E, Martini, R, IJzerman, AP, Sauer, DB, Heitman, LH, Manolova, V, Reinhardt, J, Ehrmann, A, Leippe, P, Ecker, GF, Huber, KVM, Licher, T, Scarabottolo, L, Wiedmer, T & Superti-Furga, G 2024, 'Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily', Frontiers in Pharmacology, vol. 15, 1401599. https://doi.org/10.3389/fphar.2024.1401599
Granulo, N, Sosnin, S, Digles, D & Ecker, GF 2024, 'The macrocycle inhibitor landscape of SLC‐transporter', Molecular Informatics, vol. 43, no. 5, e202300287. https://doi.org/10.1002/minf.202300287
Huang, J, Osthushenrich, T, MacNamara, A, Mälarstig, A, Brocchetti, S, Bradberry, S, Scarabottolo, L, Ferrada, E, Sosnin, S, Digles, D, Superti-Furga, G & Ecker, GF 2024, 'ProteoMutaMetrics: machine learning approaches for solute carrier family 6 mutation pathogenicity prediction', Rsc advances, vol. 14, no. 19, 00748, pp. 13083-13094. https://doi.org/10.1039/d4ra00748d
Ferrada, E, Wiedmer, T, Wang, WA, Frommelt, F, Steurer, B, Klimek, C, Lindinger, S, Osthushenrich, T, Garofoli, A, Brocchetti, S, Bradberry, S, Huang, J, MacNamara, A, Scarabottolo, L, Ecker, GF, Malarstig, A & Superti-Furga, G 2024, 'Experimental and Computational Analysis of Newly Identified Pathogenic Mutations in the Creatine Transporter SLC6A8', Journal of Molecular Biology, vol. 436, no. 2, 168383. https://doi.org/10.1016/j.jmb.2023.168383
Activities
Showing entries 76 - 80 out of 202
Insights into the binding mode of propafenone type P-gp inhibitors.
Freya Klepsch
,
Ruben Vosmeer
,
Daan Geerke
,
Chris Oostenbrink
,
Gerhard Ecker
241st American Chemical Society National Meeting & Exposition (ACS 2011)
Conference,
Poster presentation
..2011 - ..2011
Ligand based screening for insulin mimetic compounds.
Daniela Digles
,
Elke Heiß
,
Verena Dirsch
,
Gerhard Ecker
Joint Meeting of the Austrian and German Pharmaceutical Societies
Conference,
Poster presentation
..2011 - ..2011
Ligand-Based Classification Model for Imbalanced Dataset of P-Glycoprotein Substrates and Non-Substrates.
Yogesh Aher
,
Vasanthanathan Poongavanam
,
Gerhard Ecker
8th European Workshop in Drug Design
Seminar/Workshop,
Poster presentation
..2011 - ..2011
Machine Learning and Pharmacophore-Based Models as an Efficient Virtual Screening Tool for Identification of P-Glycoprotein Inhibitors
Norbert Haider
,
Gerhard Ecker
,
Yogesh Aher
,
Vasanthanathan Poongavanam
Joint Meeting of the Austrian and German Pharmaceutical Societies
Conference,
Poster presentation
..2011 - ..2011
Molecular Dynamics - Assisted Comparative Modeling and Docking Studies of the Gamma-Aminobutyric Acid Transporter
Andreas Jurik
,
Barbara Zdrazil
,
Regina Reicherstorfer
,
Harald H. Sitte
,
Gerhard Ecker
4th Annual SFB Symposium "Transmembrane Transporters in Health and Disease"
Conference,
Poster presentation
..2011 - ..2011