A method for the synthesis of 2,3-disubstituted 2,3-dihydrobenzofurans
- Author(s)
- Danilo Annibali, Gerhard Ecker, Wilhelm Fleischhacker, Thomas Helml, Wolfgang Holzer, Christian Noe
- Abstract
The synthesis of 2,3-disubstituted 2,3-dihydrobenzofuran diastereomers is described. The key step in the reaction sequence is the chemoselective reduction of a tert. alcohole with tert.-butylamine-borane/AICl3. The relative configuration of the substituents on the dihydrofurane moiety was assigned via NMR spectroscopy.
- Organisation(s)
- External organisation(s)
- Universität Wien
- Journal
- Monatshefte für Chemie
- Volume
- 131
- Pages
- 375-382
- No. of pages
- 8
- ISSN
- 0026-9247
- DOI
- https://doi.org/10.1007/s007060050318
- Publication date
- 2000
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 3012 Pharmacy, Pharmacology, Toxicology
- Portal url
- https://ucris.univie.ac.at/portal/en/publications/a-method-for-the-synthesis-of-23disubstituted-23dihydrobenzofurans(cdb16222-f4de-42e5-80b0-911de1bda159).html