Transporters in Hepatotoxicity
- Author(s)
- Eleni Kotsampasakou, Sankalp Jain, Daniela Digles, Gerhard F. Ecker
- Abstract
Diaz Ochoa developed a multiscale modeling framework for spatiotemporal prediction of substances' distribution that may result in hepatotoxicity. The recent modeling approaches in the authors's lab concerning prediction of hepatotoxicity endpoints by incorporating transporter interaction profiles follow the multiscale model concept. For canalicular transporters, the most prominent example is the contribution of both genetically and drug-induced bile salt export pump (BSEP) inhibition in the development of cholestatic conditions. Considerable progress has been made in the development of in silico prediction models for canalicular transporters such as BSEP and breast cancer resistance protein (BCRP). In addition, there were also recent advances for in silico models for basolateral transporters. It has been proposed that the mechanistic basis of some hepatotoxic and, in particular, cholestatic drugs includes the inhibition of sodium (Na+) taurocholateco-transporting polypeptide (NTCP).
- Organisation(s)
- Pages
- 145-174
- No. of pages
- 30
- DOI
- https://doi.org/10.1002/9781119282594.ch6
- Publication date
- 02-2018
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 301207 Pharmaceutical chemistry
- Keywords
- ASJC Scopus subject areas
- Chemistry(all), Chemical Engineering(all), Computer Science(all), Pharmacology, Toxicology and Pharmaceutics(all)
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/transporters-in-hepatotoxicity(4475748a-718c-4f63-b191-4431546ac7b4).html