Comparison of different methods for estimation of lipophilicity of propafenone-type modulators of multidrug resistance
- Author(s)
- S. Prets, A. Jungreithmair, P. Chiba, G. Ecker
- Abstract
Lipophilicity values of a series of 23 propafenone-type MDR-modulators were estimated using various software packages and compared with lipophilicity indices obtained by an HPLC method. Best correlations were obtained for MOLGEN® (r = 0.990) and the spl-macro 'logP' from SYBYL® (r = 0.980).
- Organisation(s)
- External organisation(s)
- Universität Wien
- Journal
- Scientia Pharmaceutica
- Volume
- 64
- Pages
- 627-636
- No. of pages
- 10
- ISSN
- 0036-8709
- Publication date
- 09-1996
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 301207 Pharmaceutical chemistry
- Keywords
- ASJC Scopus subject areas
- Pharmaceutical Science
- Portal url
- https://ucris.univie.ac.at/portal/en/publications/comparison-of-different-methods-for-estimation-of-lipophilicity-of-propafenonetype-modulators-of-multidrug-resistance(080ed009-987c-426f-b432-ebe03ce9637b).html