Insights into Transporter Classifications: an Outline of Transporters as Drug Targets
- Author(s)
- Michael Viereck, Anna Gaulton, Daniela Digles
- Abstract
In the case of the identification of drug targets (including transporters as the main drug target), several publications show classifications as a helpful tool. This chapter presents an overview on selected existing transporter classifications and then describes the process of creating a combined classification scheme for the ChEMBL database. It provides the investigation of the counts of drugs and diseases for one example protein superfamily to show the usefulness of classifications in characterizing related proteins. The chapter discusses the functional and phylogenetic classification scheme of the Transporter Classification Database (TCDB), the more pharmacology-driven IUPHAR/BPS classification, and the mainly functional-driven classification of channels and transporters in the bioactivity database ChEMBL-16. It then talks about the solute carriers (SLC) families to give an overview of interacting drugs and associated diseases of members of the amino acid-polyamine-organocation (APC) clan.
- Organisation(s)
- External organisation(s)
- European Bioinformatics Institute
- Pages
- 1-20
- No. of pages
- 20
- DOI
- https://doi.org/10.1002/9783527679430.ch1
- Publication date
- 02-2017
- Austrian Fields of Science 2012
- 301207 Pharmaceutical chemistry
- Keywords
- ASJC Scopus subject areas
- General Chemistry, General Pharmacology, Toxicology and Pharmaceutics, General Medicine
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/daa3d01a-df2a-4f64-9214-f70d4c88b673