Ligand Desolvation steers on-rate and impacts Drug Residence Time of Heat shock protein 90 (Hsp90) Inhibitors
- Author(s)
- Doris Alexandra Schuetz, Lars Richter, Marta Amaral, Melanie Grandits, Ulrich Graedler, Djordje Musil, Hans-Peter Buchstaller, Hans-Michael Eggenweiler, Matthias Frech, Gerhard F Ecker
- Organisation(s)
- External organisation(s)
- Merck KGaA, iBET - Instituto de Biologia Experimental e Tecnológica
- Journal
- Journal of Medicinal Chemistry
- Volume
- 61
- Pages
- 4397–4411
- No. of pages
- 15
- ISSN
- 0022-2623
- DOI
- https://doi.org/10.1021/acs.jmedchem.8b00080
- Publication date
- 05-2018
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 106041 Structural biology
- Keywords
- ASJC Scopus subject areas
- Drug Discovery, Molecular Medicine
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/7165d8cb-8fc0-4718-8778-c9378fb6c4ab