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Dipl.-Ing. (FH) Dr. Daniela Digles

T: +43-1-4277-55007

daniela.digles@univie.ac.at

Winter term 2023

262006 UE Introduction to Computational Biology and Drug Discovery - Exercises

321007 VO Statistik für PharmazeutInnen - BA7 - B3

321024 PR Arzneistoffanalytik - B12 - (5 Kurse)

321026 VU Pharmazeutisches Imaging - B13 - (5 Kurse)

321031 PR Biochemische und vertiefende pharmazeutisch-chemische Arbeitstechniken - B17 - (6 Kurse)

321131 PR Biochemische und vertiefende pharmazeutisch-chemische Arbeitstechniken - B17 - Zusatzkurse - (4 Kurse)

Summer term 2023

321013 PR Arzneistoffsynthese - B7 - (5 Kurse)

321024 PR Arzneistoffanalytik - B12 - (5 Kurse)

321031 PR Biochemische und vertiefende pharmazeutisch-chemische Arbeitstechniken - B17 - (6 Kurse)

321131 PR Biochemische und vertiefende pharmazeutisch-chemische Arbeitstechniken - B17 - Zusatzkurse - (5 Kurse)

323007 UE Experimental Methods in Drug Discovery und Preclinical Drug Development - MPS6 - (2 Courses)

323101 VU Pharmacoinformatics - MPS5

323102 VU Pharmacoinformatics Practical Course - MPS5

Winter term 2022

321007 VO Statistik für PharmazeutInnen - BA7 - B3

321024 PR Arzneistoffanalytik - B12 - (5 Kurse)

321031 PR Biochemische und vertiefende pharmazeutisch-chemische Arbeitstechniken - B17 - (6 Kurse)

321131 PR Biochemische und vertiefende pharmazeutisch-chemische Arbeitstechniken - B17 - Zusatzkurse - (5 Kurse)

Hanspers, K, Kutmon, M, Coort, SL, Digles, D, Dupuis, LJ, Ehrhart, F, Hu, F, Lopes, EN, Martens, M, Pham, N, Shin, W, Slenter, DN, Waagmeester, A, Willighagen, EL, Winckers, LA, Evelo, CT & Pico, AR 2021, 'Ten simple rules for creating reusable pathway models for computational analysis and visualization', PLoS Computational Biology, vol. 17, no. 8, e1009226. https://doi.org/10.1371/journal.pcbi.1009226

Dvorak, V, Wiedmer, T, Ingles-Prieto, A, Altermatt, P, Batoulis, H, Bärenz, F, Bender, E, Digles, D, Dürrenberger, F, Heitman, LH, IJzerman, AP, Kell, DB, Kickinger, S, Körzö, D, Leippe, P, Licher, T, Manolova, V, Rizzetto, R, Sassone, F, Scarabottolo, L, Schlessinger, A, Schneider, V, Sijben, HJ, Steck, A-L, Sundström, H, Tremolada, S, Wilhelm, M, Wright Muelas, M, Zindel, D, Steppan, CM & Superti-Furga, G 2021, 'An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters', Frontiers in Pharmacology, vol. 12, 722889. https://doi.org/10.3389/fphar.2021.722889

Martens, M, Ammar, A, Riutta, A, Waagmeester, A, Slenter, DN, Hanspers, K, Miller, R, Digles, D, Lopes, E, Ehrhart, F, Dupuis, L, Winckers, L, Coort, SL, Willighagen, EL, Evelo, CT, Pico, AR & Kutmon, M 2021, 'WikiPathways: Connecting Communities', Nucleic Acids Research, vol. 49, no. D1, pp. D613–D621. https://doi.org/10.1093/nar/gkaa1024

Superti-Furga, G, Lackner, D, Wiedmer, T, Ingles-Prieto, A, RESOLUTE consortium & Steppan, C 2020, 'The RESOLUTE consortium: unlocking SLC transporters for drug discovery', Nature Reviews. Drug Discovery, vol. 19, no. 7, pp. 429-430. https://doi.org/10.1038/d41573-020-00056-6

Hemmerich, J, Gurinova, J & Digles, D 2020, 'Accessing public compound databases with KNIME', Current Medicinal Chemistry, vol. 27, no. 38, pp. 6444-6457. https://doi.org/10.2174/0929867326666190801152317

Miller, RA, Woollard, P, Willighagen, EL, Digles, D, Kutmon, M, Loizou, A, Waagmeester, A, Senger, S & Evelo, CT 2018, 'Explicit interaction information from WikiPathways in RDF facilitates drug discovery in the Open PHACTS Discovery Platform', F1000Research, vol. 7, 75. https://doi.org/10.12688/F1000RESEARCH.13197.2

Digles, D, Dangl, A, Senger, S & Ecker, G 2018, 'Open PHACTS – Semantische Datenintegration für die pharmazeutische Forschung: Open PHACTS – Semantic data integration for pharmaceutical research ', Pharmakon, vol. 6, no. 4, pp. 268-275. https://doi.org/10.1691/pn.20180026

Digles, D, Caracoti, A & Jacoby, E 2018, Accessing the Open PHACTS Discovery Platform with Workflow Tools. in B Wagner (ed.), Phenotypic Screening: Methods and Protocols. Springer, New York, Methods in Molecular Biology, vol. 1787, pp. 183-193. https://doi.org/10.1007/978-1-4939-7847-2_14

Kotsampasakou, E, Jain, S, Digles, D & Ecker, GF 2018, Transporters in Hepatotoxicity. in Computational Toxicology: Risk Assessment for Chemicals. Wiley, pp. 145-174. https://doi.org/10.1002/9781119282594.ch6

Slenter, DN, Kutmon, M, Hanspers, K, Riutta, A, Windsor, J, Nunes, N, Mélius, J, Cirillo, E, Coort, SL, Digles, D, Ehrhart, F, Giesbertz, P, Kalafati, M, Martens, M, Miller, R, Nishida, K, Rieswijk, L, Waagmeester, A, Eijssen, LMT, Evelo, CT, Pico, AR & Willighagen, EL 2018, 'WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research', Nucleic Acids Research, vol. 46, no. D1, pp. D661–D667. https://doi.org/10.1093/nar/gkx1064

Goldmann, D, Zdrazil, B, Digles, D & Ecker, GF 2017, 'Empowering pharmacoinformatics by linked life science data', Journal of Computer-Aided Molecular Design, vol. 31, no. 3, pp. 319-328. https://doi.org/10.1007/s10822-016-9990-4

Viereck, M, Gaulton, A & Digles, D 2017, Insights into Transporter Classifications: an Outline of Transporters as Drug Targets. in Transporters as Drug Targets. Wiley-VCH Verlag, pp. 1-20. https://doi.org/10.1002/9783527679430.ch1

Montanari, F, Zdrazil, B, Digles, D & Ecker, GF 2016, 'Selectivity profiling of BCRP versus P-gp inhibition: from automated collection of polypharmacology data to multi-label learning', Journal of Cheminformatics, vol. 8, no. 1, 7, pp. 7. https://doi.org/10.1186/s13321-016-0121-y

Digles, D, Zdrazil, B, Neefs, JM, Van Vlijmen, H, Herhaus, C, Caracoti, A, Brea, J, Roibás, B, Loza, MI, Queralt-Rosinach, N, Furlong, LI, Gaulton, A, Bartek, L, Senger, S, Chichester, C, Engkvist, O, Evelo, CT, Franklin, NI, Marren, D, Ecker, GF & Jacoby, E 2016, 'Open PHACTS computational protocols for in silico target validation of cellular phenotypic screens: Knowing the knowns', MedChemComm, vol. 7, no. 6, pp. 1237-1244. https://doi.org/10.1039/c6md00065g

Chichester, C, Digles, D, Siebes, R, Loizou, A, Groth, P & Harland, L 2015, 'Drug discovery FAQs: Workflows for answering multidomain drug discovery questions', Drug Discovery Today, vol. 20, no. 4, pp. 399-405. https://doi.org/10.1016/j.drudis.2014.11.006

Ratnam, J, Zdrazil, B, Digles, D, Cuadrado-Rodriguez, E, Neefs, J-M, Tipney, H, Siebes, R, Waagmeester, A, Bradley, G, Chau, CH, Richter, L, Brea, J, Evelo, CT, Jacoby, E, Senger, S, Loza, MI, Ecker, GF & Chichester, C 2014, 'The Application of the Open Pharmacological Concepts Triple Store (Open PHACTS) to Support Drug Discovery Research', PLoS ONE, vol. 9, no. 12, e115460. https://doi.org/10.1371/journal.pone.0115460

Pinto, M, Digles, D & Ecker, GF 2014, 'Computational models for predicting the interaction with ABC transporters', Drug Discovery Today: Technologies, vol. 12, pp. e69-e77. https://doi.org/10.1016/j.ddtec.2014.03.007

Viereck, M, Gaulton, A, Digles, D & Ecker, GF 2014, 'Transporter taxonomy - a comparison of different transport protein classification schemes', Drug Discovery Today: Technologies, vol. 12, pp. e37-e46. https://doi.org/10.1016/j.ddtec.2014.03.004

Batchelor, C, Brenninkmeijer, CYA, Chichester, C, Davies, M, Digles, D, Dunlop, I, Evelo, CT, Gaulton, A, Goble, C, Gray, AJG, Groth, P, Harland, L, Karapetyan, K, Loizou, A, Overington, JP, Pettifer, S, Steele, J, Stevens, R, Tkachenko, V, Waagmeester, A, Williams, A & Willighagen, EL 2014, Scientific lenses to support multiple views over linked chemistry data. in The Semantic Web – ISWC 2014: 13th International Semantic Web Conference, Riva del Garda, Italy, October 19-23, 2014. vol. Part I, Springer, Cham, Lecture Notes in Computer Science, vol. 8796, pp. 98-113, 13th International Semantic Web Conference, ISWC 2014, Riva del Garda, Italy, 19/10/14. https://doi.org/10.1007/978-3-319-11964-9_7

Digles, D & Ecker, GF 2011, 'Self-Organizing Maps for In Silico Screening and Data Visualization', Molecular Informatics, vol. 30, no. 10, pp. 838-846. https://doi.org/10.1002/minf.201100082

Accessing public databases with KNIME

Daniela Digles (Speaker)

17 Sep 2019

Activity: Talks and presentations › Talk or oral contribution › Science to Science

ReSOLUTE databases and tools for the scientific community

Daniela Digles (Speaker)

20 Sep 2018

Activity: Talks and presentations › Talk or oral contribution › Science to Science