Empowering pharmacoinformatics by linked life science data

Author(s)
Daria Goldmann, Barbara Zdrazil, Daniela Digles, Gerhard F Ecker
Abstract

With the public availability of large data sources such as ChEMBLdb and the Open PHACTS Discovery Platform, retrieval of data sets for certain protein targets of interest with consistent assay conditions is no longer a time consuming process. Especially the use of workflow engines such as KNIME or Pipeline Pilot allows complex queries and enables to simultaneously search for several targets. Data can then directly be used as input to various ligand- and structure-based studies. In this contribution, using in-house projects on P-gp inhibition, transporter selectivity, and TRPV1 modulation we outline how the incorporation of linked life science data in the daily execution of projects allowed to expand our approaches from conventional Hansch analysis to complex, integrated multilayer models.

Organisation(s)
Department of Pharmaceutical Chemistry
Journal
Journal of Computer-Aided Molecular Design
Volume
31
Pages
319-328
ISSN
0920-654X
DOI
https://doi.org/10.1007/s10822-016-9990-4
Publication date
11-2016
Peer reviewed
Yes
Austrian Fields of Science 2012
Pharmaceutical chemistry
Portal url
https://ucris.univie.ac.at/portal/en/publications/empowering-pharmacoinformatics-by-linked-life-science-data(dc502dc3-3307-4b76-9c76-6a98cf08abb6).html