Drug discovery FAQs

Author(s)
Christine Chichester, Daniela Digles, Ronald Siebes, Antonis Loizou, Paul Groth, Lee Harland
Abstract

Modern data-driven drug discovery requires integrated resources to support decision-making and enable new discoveries. The Open PHACTS Discovery Platform (http://dev.openphacts.org) was built to address this requirement by focusing on drug discovery questions that are of high priority to the pharmaceutical industry. Although complex, most of these frequently asked questions (FAQs) revolve around the combination of data concerning compounds, targets, pathways and diseases. Computational drug discovery using workflow tools and the integrated resources of Open PHACTS can deliver answers to most of these questions. Here, we report on a selection of workflows used for solving these use cases and discuss some of the research challenges. The workflows are accessible online from myExperiment (http://www.myexperiment.org) and are available for reuse by the scientific community.

Organisation(s)
Department of Pharmaceutical Chemistry
External organisation(s)
Swiss Institute of Bioinformatics, Vrije Universiteit Amsterdam, Connected Discovery Ltd
Journal
Drug Discovery Today
Volume
20
Pages
399-405
No. of pages
7
ISSN
1359-6446
DOI
https://doi.org/10.1016/j.drudis.2014.11.006
Publication date
04-2015
Peer reviewed
Yes
Austrian Fields of Science 2012
Pharmaceutical chemistry
ASJC Scopus subject areas
,
Portal url
https://ucris.univie.ac.at/portal/en/publications/drug-discovery-faqs(8cb7b053-441e-41fe-bdc3-6bf82b675598).html