Transporters in Hepatotoxicity

Author(s)
Eleni Kotsampasakou, Sankalp Jain, Daniela Digles, Gerhard F. Ecker
Abstract

Diaz Ochoa developed a multiscale modeling framework for spatiotemporal prediction of substances' distribution that may result in hepatotoxicity. The recent modeling approaches in the authors's lab concerning prediction of hepatotoxicity endpoints by incorporating transporter interaction profiles follow the multiscale model concept. For canalicular transporters, the most prominent example is the contribution of both genetically and drug-induced bile salt export pump (BSEP) inhibition in the development of cholestatic conditions. Considerable progress has been made in the development of in silico prediction models for canalicular transporters such as BSEP and breast cancer resistance protein (BCRP). In addition, there were also recent advances for in silico models for basolateral transporters. It has been proposed that the mechanistic basis of some hepatotoxic and, in particular, cholestatic drugs includes the inhibition of sodium (Na+) taurocholateco-transporting polypeptide (NTCP).

Organisation(s)
Department of Pharmaceutical Chemistry
Pages
145-174
No. of pages
30
DOI
https://doi.org/10.1002/9781119282594.ch6
Publication date
02-2018
Peer reviewed
Yes
Austrian Fields of Science 2012
Pharmaceutical chemistry
Keywords
ASJC Scopus subject areas
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Portal url
https://ucris.univie.ac.at/portal/en/publications/transporters-in-hepatotoxicity(4475748a-718c-4f63-b191-4431546ac7b4).html