Explicit interaction information from WikiPathways in RDF facilitates drug discovery in the Open PHACTS Discovery Platform

Author(s)
Ryan A. Miller, Peter Woollard, Egon L. Willighagen, Daniela Digles, Martina Kutmon, Antonis Loizou, Andra Waagmeester, Stefan Senger, Chris T. Evelo
Abstract

Open PHACTS is a pre-competitive project to answer scientific questions developed recently by the pharmaceutical industry. Having high quality biological interaction information in the Open PHACTS Discovery Platform is needed to answer multiple pathway related questions. To address this, updated WikiPathways data has been added to the platform. This data includes information about biological interactions, such as stimulation and inhibition. The platform's Application Programming Interface (API) was extended with appropriate calls to reference these interactions. These new methods of the Open PHACTS API are available now.

Organisation(s)
Department of Pharmaceutical Chemistry
External organisation(s)
University Hospital Maastricht, GlaxoSmithKline, Maastricht Center for Systems Biology (MaCSBio), Micelio, Open PHACTS Foundation, Blue Sky IT
Journal
F1000Research
Volume
7
DOI
https://doi.org/10.12688/f1000research.13197.1
Publication date
10-2018
Peer reviewed
Yes
Austrian Fields of Science 2012
Pharmaceutical chemistry
Keywords
ASJC Scopus subject areas
, ,
Portal url
https://ucris.univie.ac.at/portal/en/publications/explicit-interaction-information-from-wikipathways-in-rdf-facilitates-drug-discovery-in-the-open-phacts-discovery-platform(131a05dc-c063-4d3d-984f-2c5595e45938).html