Explicit interaction information from WikiPathways in RDF facilitates drug discovery in the Open PHACTS Discovery Platform
- Author(s)
- Ryan A. Miller, Peter Woollard, Egon L. Willighagen, Daniela Digles, Martina Kutmon, Antonis Loizou, Andra Waagmeester, Stefan Senger, Chris T. Evelo
- Abstract
Open PHACTS is a pre-competitive project to answer scientific questions developed recently by the pharmaceutical industry. Having high quality biological interaction information in the Open PHACTS Discovery Platform is needed to answer multiple pathway related questions. To address this, updated WikiPathways data has been added to the platform. This data includes information about biological interactions, such as stimulation and inhibition. The platform's Application Programming Interface (API) was extended with appropriate calls to reference these interactions. These new methods of the Open PHACTS API are available now.
- Organisation(s)
- External organisation(s)
- Maastricht University Medical Center, GlaxoSmithKline, Maastricht University (UM), Micelio, Open PHACTS Foundation, Blue Sky Group
- Journal
- F1000Research
- Volume
- 7
- Publication date
- 10-2018
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 301207 Pharmaceutical chemistry
- Keywords
- ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all), Immunology and Microbiology(all), Pharmacology, Toxicology and Pharmaceutics(all)
- Portal url
- https://ucris.univie.ac.at/portal/en/publications/explicit-interaction-information-from-wikipathways-in-rdf-facilitates-drug-discovery-in-the-open-phacts-discovery-platform(131a05dc-c063-4d3d-984f-2c5595e45938).html