Follow me on Twitter

I agree that content from Twitter will be displayed to me.

 

Postdoc

Claire completed her PhD in 2011 at the Pasteur Institute in Paris, France and worked for two years as a postdoctoral scientist at the Institut de Chimie des Substances Naturelles at Gif-sur-Yvette, France. Since 2013, her research has been focused on the structural characterization of Solute Carrier (SLC) transporters. In humans, there are over 450 SLCs that transport a broad range of substrates, including neurotransmitters, metabolites, and drugs. Thus, SLCs are emerging as important therapeutic targets. First at the mount Sinai School of Medicine in New-York City (2013-2018) and then in Vienna (2018-present), Claire has been working on six distinct SLC families, involved in various diseases and disorders. She uses various computational methods such as homology modeling and molecular docking to explore the structural determinants defining the substrate specificities of SLCs.

Publications

Showing entries 16 - 20 out of 28
Singh K, Tanui R, Gameiro A, Eisenberg G, Colas C, Schlessinger A et al. Structure activity relationships of benzylproline-derived inhibitors of the glutamine transporter ASCT2. Bioorganic & Medicinal Chemistry Letters. 2017 Feb 1;27(3):398-402. doi: 10.1016/j.bmcl.2016.12.063

Zur AA, Chien HC, Augustyn E, Flint A, Heeren N, Finke K et al. LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates. Bioorganic & Medicinal Chemistry Letters. 2016 Sept 3;26(20):5000-5006. doi: 10.1016/j.bmcl.2016.09.001

Augustyn E, Finke K, Zur AA, Hansen L, Heeren N, Chien HC et al. LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs. Bioorganic & Medicinal Chemistry Letters. 2016 Jun 1;26(11):2616-2621. doi: 10.1016/j.bmcl.2016.04.023

Klotz J, Porter BE, Colas C, Schlessinger A, Pajor AM. Mutations in the Na(+)/citrate cotransporter NaCT (SLC13A5) in pediatric patients with epilepsy and developmental delay. Molecular Medicine. 2016 May 26;22:310-321. doi: 10.2119/molmed.2016.00077

Colas C, Ung PM, Schlessinger A. SLC Transporters: Structure, Function, and Drug Discovery. MedChemComm. 2016 Mar 28;7(6):1069-1081. doi: 10.1039/C6MD00005C