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Postdoc

Claire completed her PhD in 2011 at the Pasteur Institute in Paris, France and worked for two years as a postdoctoral scientist at the Institut de Chimie des Substances Naturelles at Gif-sur-Yvette, France. Since 2013, her research has been focused on the structural characterization of Solute Carrier (SLC) transporters. In humans, there are over 450 SLCs that transport a broad range of substrates, including neurotransmitters, metabolites, and drugs. Thus, SLCs are emerging as important therapeutic targets. First at the mount Sinai School of Medicine in New-York City (2013-2018) and then in Vienna (2018-present), Claire has been working on six distinct SLC families, involved in various diseases and disorders. She uses various computational methods such as homology modeling and molecular docking to explore the structural determinants defining the substrate specificities of SLCs.

Publications

Showing entries 26 - 28 out of 28
Prevost MS, Delarue-Cochin S, Marteaux J, Colas C, Van Renterghem C, Blondel A et al. Identification of cinnamic acid derivatives as novel antagonists of the prokaryotic proton-gated ion channel GLIC. Journal of Medicinal Chemistry. 2013 Jun 13;56(11):4619-4630. doi: 10.1021/jm400374q

Taly A, Colas C, Malliavin T, Blondel A, Nilges M, Corringer PJ et al. Discrimination of agonists versus antagonists of nicotinic ligands based on docking onto AChBP structures. Journal of molecular graphics & modelling. 2011 Sept;30:100-109. doi: 10.1016/j.jmgm.2011.06.008