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Postdoc

Claire completed her PhD in 2011 at the Pasteur Institute in Paris, France and worked for two years as a postdoctoral scientist at the Institut de Chimie des Substances Naturelles at Gif-sur-Yvette, France. Since 2013, her research has been focused on the structural characterization of Solute Carrier (SLC) transporters. In humans, there are over 450 SLCs that transport a broad range of substrates, including neurotransmitters, metabolites, and drugs. Thus, SLCs are emerging as important therapeutic targets. First at the mount Sinai School of Medicine in New-York City (2013-2018) and then in Vienna (2018-present), Claire has been working on six distinct SLC families, involved in various diseases and disorders. She uses various computational methods such as homology modeling and molecular docking to explore the structural determinants defining the substrate specificities of SLCs.

Publications

Showing entries 11 - 15 out of 28
Chien HC, Colas C, Finke K, Springer S, Stoner L, Zur AA et al. Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1). Journal of Medicinal Chemistry. 2018 Aug 23;61(16):7358-7373. doi: 10.1021/acs.jmedchem.8b01007

Garibsingh RAA, Otte NJ, Ndaru E, Colas C, Grewer C, Holst J et al. Homology modeling informs ligand discovery for the glutamine transporter ASCT2. Frontiers in Chemistry. 2018 Jul 24;6:279. doi: 10.3389/fchem.2018.00279

Colas C, Masuda M, Sugio K, Miyauchi S, Hu Y, Smith DE et al. Chemical Modulation of the Human Oligopeptide Transporter 1, hPepT1. Molecular Pharmaceutics. 2017 Dec;14(12):4685-4693. doi: 10.1021/acs.molpharmaceut.7b00775

Colas C, Schlessinger A, Pajor AM. Mapping Functionally Important Residues in the Na+/Dicarboxylate Cotransporter, NaDC1. Biochemistry. 2017 Aug 10;56(33):4432-4441. doi: 10.1021/acs.biochem.7b00503