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Postdoc

Claire completed her PhD in 2011 at the Pasteur Institute in Paris, France and worked for two years as a postdoctoral scientist at the Institut de Chimie des Substances Naturelles at Gif-sur-Yvette, France. Since 2013, her research has been focused on the structural characterization of Solute Carrier (SLC) transporters. In humans, there are over 450 SLCs that transport a broad range of substrates, including neurotransmitters, metabolites, and drugs. Thus, SLCs are emerging as important therapeutic targets. First at the mount Sinai School of Medicine in New-York City (2013-2018) and then in Vienna (2018-present), Claire has been working on six distinct SLC families, involved in various diseases and disorders. She uses various computational methods such as homology modeling and molecular docking to explore the structural determinants defining the substrate specificities of SLCs.

Publications

Showing entries 21 - 25 out of 28
Colas C, Smith DE, Schlessinger A. Computing Substrate Selectivity in a Peptide Transporter. Cell Chemical Biology. 2016 Feb 18;23(2):211-213. doi: 10.1016/j.chembiol.2016.02.001

Colas C, Pajor AM, Schlessinger A. Structure-Based Identification of Inhibitors for the SLC13 Family of Na(+)/Dicarboxylate Cotransporters. Biochemistry. 2015 Aug 11;54(31):4900-4908. doi: 10.1021/acs.biochem.5b00388

Colas C, Grewer C, Otte NJ, Gameiro A, Albers T, Singh K et al. Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening. PLoS Computational Biology. 2015;11(10):e1004477. e1004477. doi: 10.1371/journal.pcbi.1004477

Desrat S, Pujals A, Colas C, Dardenne J, Gény C, Favre L et al. Pro-apoptotic meiogynin A derivatives that target Bcl-xL and Mcl-1. Bioorganic & Medicinal Chemistry Letters. 2014 Nov 1;24(21):5086-5088. doi: 10.1016/j.bmcl.2014.09.004

Schlessinger A, Sun NN, Colas C, Pajor AM. Determinants of substrate and cation transport in the human Na+/dicarboxylate cotransporter NaDC3. Journal of Biological Chemistry. 2014 Jun 13;289(24):16998-17008. doi: 10.1074/jbc.M114.554790