Ligand Desolvation steers on-rate and impacts Drug Residence Time of Heat shock protein 90 (Hsp90) Inhibitors

Author(s)
Doris Alexandra Schuetz, Lars Richter, Marta Amaral, Melanie Grandits, Ulrich Graedler, Djordje Musil, Hans-Peter Buchstaller, Hans-Michael Eggenweiler, Matthias Frech, Gerhard F Ecker
Organisation(s)
External organisation(s)
Merck KGaA, iBET - Instituto de Biologia Experimental e Tecnológica
Journal
Journal of Medicinal Chemistry
Volume
61
Pages
4397–4411
No. of pages
15
ISSN
0022-2623
DOI
https://doi.org/10.1021/acs.jmedchem.8b00080
Publication date
05-2018
Peer reviewed
Yes
Austrian Fields of Science 2012
106041 Structural biology
Keywords
ASJC Scopus subject areas
Drug Discovery, Molecular Medicine
Portal url
https://ucris.univie.ac.at/portal/en/publications/ligand-desolvation-steers-onrate-and-impacts-drug-residence-time-of-heat-shock-protein-90-hsp90-inhibitors(7165d8cb-8fc0-4718-8778-c9378fb6c4ab).html