PhD student

Stefanie generated new homology models of the GABA transporter hBGT1 based on the recently released crystal structure of the human serotonin transporter. With the help of docking and molecular dynamics simulations she is currently studying competitive and non-competitive hBGT1 inhibitors.  Non-competitive hBGT1 inhibitors possibly bind to a new allosteric binding pocket. In the future, Stefanie will further study how this pocket could contribute to the selectivity profile of GABA and taurine transporters.

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Publications and Activities

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Kickinger S, Hellsberg E, Jain S, Ecker GF. Linked open data: Ligand-transporter interaction profiling and beyond. In Methods in Pharmacology and Toxicology. Humana Press, Inc. 2019. p. 405-417. (Methods in Pharmacology and Toxicology).

Damgaard M, Haugaard AS, Kickinger S, Al-Khawaja A, Lie MEK, Ecker G et al. Development of Non-GAT1-Selective Inhibitors: Challenges and Achievements. In Ortega A, Schousboe A, editors, Glial Amino Acid Transporters. Springer. 2017. (Advances in Neurobiology).

Showing entries 0 - 5 out of 5