Structural insight into the in vitro anti-intravasative properties of flavonoids

Author(s)
Julia Eichsteininger, Kerstin Kirisits, Claudia Smöch, Christa Stadlbauer, Chi Huu Nguyen, Walter Jäger, Ali Özmen, Gerhard Ecker, Georg Krupitza, Liselotte Krenn
Abstract

We investigated the effect of 21 flavonoids in a three-dimensional in vitro system for their ability to inhibit gap formation by MCF-7 breast cancer spheroids in monolayers of lymphendothelial cells. Different representatives of the classes of flavones, flavonols, and flavanones were tested in the circular chemorepellent-induced defects (CCID)-assay. Bay11-7082, a known inhibitor of CCID formation served as the positive control. This study provides the first comparison of the potential of flavonoids to suppress features influencing the intravasation of MCF-7 breast cancer cells aggregates through the lymph endothelial barrier. The most significant effects were seen after incubation with the flavones luteolin, chrysin, and apigenin. Additional hydroxylation or methoxylation in positions 6 or 8, as expected, resulted in decreased activity. The tested flavanones remained without or low efficacy.

Organisation(s)
Department of Pharmacognosy, Department of Pharmaceutical Chemistry
External organisation(s)
Medizinische Universität Wien, Universität Wien, Adnan Menderes University
Journal
Scientia Pharmaceutica
Volume
87
ISSN
0036-8709
DOI
https://doi.org/10.3390/scipharm87030023
Publication date
09-2019
Peer reviewed
Yes
Austrian Fields of Science 2012
Pharmacy
Keywords
ASJC Scopus subject areas
Portal url
https://ucris.univie.ac.at/portal/en/publications/structural-insight-into-the-in-vitro-antiintravasative-properties-of-flavonoids(ed96a24f-aa12-4ab0-adc9-f93aed529baa).html