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PhD student

Florentina is focussing on mitochondrial toxicity predictions by using structure based methods such as docking and structure-based pharamcophore modeling. Her major interest is the first complex of the mitochondrial respiratory chain which is crucial for the oxidative phosphorylation and in this way for energy creation in form of ATP. Inhibition of human mitochondrial respiratory complex I is linked to Parkinson’s disease which makes it a relevant off-target. This study is conducted within the EU-ToxRisk project. Additionally, Florentina is performing structure-based modeling studies on SLC25 family members within RESOLUTE.