Targeting Solute Carrier Transporters through Functional Mapping

Author(s)
Claire Colas, Elodie Laine
Abstract

Solute carrier (SLC) transporters are emerging drug targets. Identifying the molecular determinants responsible for their specific and selective transport activities and describing key interactions with their ligands are crucial steps towards the design of potential new drugs. A general functional mapping across more than 400 human SLC transporters would pave the way to the rational and systematic design of molecules modulating cellular transport.

Organisation(s)
External organisation(s)
Université Paris VI - Pierre-et-Marie-Curie
Journal
Trends in Pharmacological Sciences
Volume
42
Pages
3-6
ISSN
0165-6147
DOI
https://doi.org/10.1016/j.tips.2020.11.005
Publication date
11-2020
Peer reviewed
Yes
Austrian Fields of Science 2012
106002 Biochemistry, 106041 Structural biology
Portal url
https://ucris.univie.ac.at/portal/en/publications/targeting-solute-carrier-transporters-through-functional-mapping(00d846f1-b5a4-4441-adf6-9b35ae8f75e4).html