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Postdoc
Claire completed her PhD in 2011 at the Pasteur Institute in Paris, France and worked for two years as a postdoctoral scientist at the Institut de Chimie des Substances Naturelles at Gif-sur-Yvette, France. Since 2013, her research has been focused on the structural characterization of Solute Carrier (SLC) transporters. In humans, there are over 450 SLCs that transport a broad range of substrates, including neurotransmitters, metabolites, and drugs. Thus, SLCs are emerging as important therapeutic targets. First at the mount Sinai School of Medicine in New-York City (2013-2018) and then in Vienna (2018-present), Claire has been working on six distinct SLC families, involved in various diseases and disorders. She uses various computational methods such as homology modeling and molecular docking to explore the structural determinants defining the substrate specificities of SLCs.
Hall C, Wolfe H, Wells A, Chien H-C, Colas C, Schlessinger A et al. l-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of l-histidine and l-tryptophan. Bioorganic & Medicinal Chemistry Letters. 2019 Aug 15;29(16):2254-2258. doi.org/10.1016/j.bmcl.2019.06.033
Viktoria G, Colas C, Ecker GF. Structural Determinants of the hASBT-Ligands Interactions. Biophysical Journal. 2019 Feb 15;116(3):552A-552A. doi.org/10.1016/j.bpj.2018.11.2971
Colas C. Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1). Journal of Medicinal Chemistry. 2018 Aug 10. doi.org/10.1021/acs.jmedchem.8b01007
Garibsingh RAA, Otte NJ, Ndaru E, Colas C, Grewer C, Holst J et al. Homology modeling informs ligand discovery for the glutamine transporter ASCT2. Frontiers in Chemistry. 2018 Jul 24;6. 279. doi.org/10.3389/fchem.2018.00279