Mag. Dr. Barbara Zdrazil







Leist, M, Ghallab, A, Graepel, R, Marchan, R, Hassan, R, Bennekou, SH, Limonciel, A, Vinken, M, Schildknecht, S, Waldmann, T, Danen, E, van Ravenzwaay, B, Kamp, H, Gardner, I, Godoy, P, Bois, FY, Braeuning, A, Reif, R, Oesch, F, Drasdo, D, Höhme, S, Schwarz, M, Hartung, T, Braunbeck, T, Beltman, J, Vrieling, H, Sanz, F, Forsby, A, Gadaleta, D, Fisher, C, Kelm, J, Fluri, D, Ecker, G, Zdrazil, B, Terron, A, Jennings, P, van der Burg, B, Dooley, S, Meijer, AH, Willighagen, E, Martens, M, Evelo, C, Mombelli, E, Taboureau, O, Mantovani, A, Hardy, B, Koch, B, Escher, S, van Thriel, C, Cadenas, C, Kroese, D, van de Water, B & Hengstler, JG 2017, 'Adverse outcome pathways: opportunities, limitations and open questions' Archives of Toxicology, vol 91, no. 11, pp. 3477–3505. DOI: 10.1007/s00204-017-2045-3


Digles, D, Zdrazil, B, Neefs, JM, Van Vlijmen, H, Herhaus, C, Caracoti, A, Brea, J, Roibás, B, Loza, MI, Queralt-Rosinach, N, Furlong, LI, Gaulton, A, Bartek, L, Senger, S, Chichester, C, Engkvist, O, Evelo, CT, Franklin, NI, Marren, D, Ecker, GF & Jacoby, E 2016, 'Open PHACTS computational protocols for in silico target validation of cellular phenotypic screens: Knowing the knowns' MedChemComm, vol 7, no. 6, pp. 1237-1244. DOI: 10.1039/c6md00065g



Ratnam, J, Zdrazil, B, Digles, D, Cuadrado-Rodriguez, E, Neefs, J-M, Tipney, H, Siebes, R, Waagmeester, A, Bradley, G, Chau, CH, Richter, L, Brea, J, Evelo, CT, Jacoby, E, Senger, S, Loza, MI, Ecker, GF & Chichester, C 2014, 'The Application of the Open Pharmacological Concepts Triple Store (Open PHACTS) to Support Drug Discovery Research' PLOS ONE, vol 9, no. 12, pp. e115460. DOI: 10.1371/journal.pone.0115460

Zdrazil, B, Chichester, C, Zander Balderud, L, Engkvist, O, Gaulton, A & Overington, JP 2014, 'Transporter assays and assay ontologies: useful tools for drug discovery' Drug Discovery Today: Technologies, vol 12, pp. e47-54. DOI: 10.1016/j.ddtec.2014.03.005


Jurik, A, Zdrazil, B, Holy, M, Sitte, HH & Ecker, G 2014, 'Analyse der molekularen Basis der GABA Transporter Inhibition', Schladming, Austria, 23/02/14, .

Azzaoui, K, Jacoby, E, Senger, S, Rodríguez, EC, Loza, M, Zdrazil, B, Pinto, M, Williams, AJ, de la Torre, V, Mestres, J, Pastor, M, Taboureau, O, Rarey, M, Chichester, C, Pettifer, S, Blomberg, N, Harland, L, Williams-Jones, B & Ecker, GF 2013, 'Scientific competency questions as the basis for semantically enriched open pharmacological space development' Drug Discovery Today, vol 18, no. 17-18, pp. 843-52. DOI: 10.1016/j.drudis.2013.05.008






Seddik, A, Zdrazil, B, Stockner, T, Bulling, S, Tulzer, A, Steinkellner, T, Sandtner, W, Freissmuth, M, Sitte, HH & Ecker, G 2013, 'Prediction of high-affinity SERT substrates by 2D-QSAR'.


Jurik, A, Zdrazil, B, Sitte, HH & Ecker, G 2013, 'Virtual Screening for New GABA Transporter 1 Inhibitors Based on Insights Acquired by Comparative Modeling' 245th National Spring Meeting of the American-Chemical-Society (ACS), New Orleans , United States, 7/04/13 - 11/04/13, .



Zdrazil, B, Pinto, M, Poongavanam, V, Williams, AJ, Balderud, LZ, Engkvist, O, Chichester, C, Hersey, A, Overington, JP & Ecker, G 2012, 'Annotating Human P-Glycoprotein Bioassay Data' Molecular Informatics, vol 31, no. 8, pp. 599-609. DOI: 10.1002/minf.201200059

Jurik, A, Reicherstorfer, R, Zdrazil, B & Ecker, G 2012, 'Combining Binary QSAR and Docking for Structure-Activity Relationships of Tiagabine Analogs.' 19th EuroQSAR, Wien, Austria, 26/08/12 - 30/08/12, .

Jurik, A, Zdrazil, B, Sitte, HH, Vogensen, SB & Ecker, G 2012, 'Combining Ensemble Docking and Consensus Scoring to Elucidate the Binding Mode of Tiagabine Analogs in hGAT-1.' 3rd Strasbourg Summer School on Chemoinformatics, France, 25/06/12 - 29/06/12, .

Jurik, A, Zdrazil, B, Sitte, HH & Ecker, G 2012, 'Elucidating Binding Events of Tiagabine Analogs by Molecular Dynamics – Assisted Docking Studies.' 5th Annual SFB35 Symposium "Transmembrane Transporters in Health and Disease", Wien, Austria, 24/09/12, .

Seddik, A, Zdrazil, B, Bulling, S & Tulzer, A 2012, 'Exhaustive docking suggests equivalent orientation of Mephedrone in the human Serotonin and Dopamine transporter.' 5th Annual SFB35 Symposium "Transmembrane Transporters in Health and Disease", Wien, Austria, 24/09/12, .

Seddik, A, Weissensteiner, R, Zdrazil, B, Sitte, HH & Ecker, G 2012, 'Interaction Profiling of Mephedrone at the Human Serotonin and Dopamine Transporters.' 22nd International Symposium on Medicinal Chemistry (EFMC-ISMC 2012), Berlin, Germany, 2/09/12 - 6/09/12, .

Jurik, A, Klepsch, F & Zdrazil, B 2012, Molecular Modeling and Simulation of Membrane Transport Proteins. in D Ekinci (ed.), Medicinal Chemistry and Drug Design. InTech, pp. 373-397.

Zdrazil, B, Jurik, A, Vogensen, SB, Sitte, HH & Ecker, G 2012, 'Molecular modeling studies of the human GABA transporter 1: Insights into binding events of Tiagabine analogs' Paper presented at 244th ACS National Meeting & Exposition, Philadelphia, PA, United States, 19/08/12 - 23/08/12, .

Seddik, A, Zdrazil, B, Weissensteiner, R, Sitte, HH & Ecker, G 2012, 'Prioritization of docking poses in human serotonin and dopamine transporters by the use of common scaffold clustering' Paper presented at 244th ACS National Meeting & Exposition, Philadelphia, PA, United States, 19/08/12 - 23/08/12, .

Jurik, A, Zdrazil, B, Sitte, HH, Vogensen, SB & Ecker, G 2012, 'Studying Structure-Activity Relationships in a Homology Model of the Gamma-Aminobutyric Acid Transporter 1.' 22nd International Symposium on Medicinal Chemistry (EFMC-ISMC 2012), Berlin, Germany, 2/09/12 - 6/09/12, .

Jurik, A, Reicherstorfer, R, Zdrazil, B, Urban, E & Ecker, G 2011, 'Evaluation of Drug Binding Modes in a Series of Homology Models of the Gamma-Aminobutyric Acid Transporter.' 8th European Workshop in Drug Design, Siena, Italy, 22/05/11 - 28/05/11, .

Weissensteiner, R, Zdrazil, B, Sarker, S, Sitte, HH, Freissmuth, M, Sucic, S & Ecker, G 2011, 'Insights into Molecular Interactions between the Serotonin Transporter and Tricyclic Antidepressants.' 8th European Workshop in Drug Design, Siena, Italy, 22/05/11 - 28/05/11, .



Höltje, M, Richartz, A, Zdrazil, B, Schwanke, A, Dugovic, B, Murruzzu, C, Reissig, H-U, Korting, HC, Kleuser, B, Höltje, H-D & Schäfer-Korting, M 2010, 'Human polymerase alpha inhibitors for skin tumors. Part 2. Modeling, synthesis and influence on normal and transformed keratinocytes of new thymidine and purine derivatives' Journal of Enzyme Inhibition and Medicinal Chemistry, vol 25, no. 2, pp. 250-65. DOI: 10.3109/14756360903059579

Schwanke, A, Murruzzu, C, Zdrazil, B, Zuhse, R, Natek, M, Höltje, M, Korting, HC, Reißig, H-U, Höltje, H-D & Schäfer-Korting, M 2010, 'Antitumor effects of guanosine-analog phosphonates identified by molecular modelling' International Journal of Pharmaceutics, vol 285, pp. 10924-10938.

Höltje, M, Richartz, A, Zdrazil, B, Schwanke, A, Dugovic, B, Murruzzu, C, Reißig, H-U, Korting, HC, Kleuser, B, Höltje, H-D & Schäfer-Korting, M 2010, 'Human Polymerase α Inhibitors for Skin Tumors. Part 2. Modelling, Synthesis and Influence on Normal and Transformed Keratinocytes of New Thymidine and Purine Derivatives' Journal of Enzyme Inhibition and Medicinal Chemistry, vol 25, pp. 250-265.

Sucic, S, Dallinger, S, Zdrazil, B, Weissensteiner, R, Jorgensen, TN, Holy, M, Kudlacek, O, Seidel, S, Cha, JH, Gether, U, Newman, AH, Ecker, G, Freissmuth, M & Sitte, HH 2010, 'The N terminus of monoamine transporters is a lever required for the action of amphetamines' Journal of Biological Chemistry, vol 285, no. 14, pp. 10924-10938. DOI: 10.1074/jbc.M109.083154

Zdrazil, B & Ecker, G 2009, Cancer Drug Resistance – Targets and therapies. in Burgers Medicinal Chemistry - Drug Discovery and Development. Unknown publisher.










How popular is my scaffold? - A trend analysis of scaffold properties over time

Zdrazil, B. (Speaker)
19 Sep 2017

Activity: Science to ScienceTalk or oral contribution


Department für Pharmazeutische Chemie

Althanstraße 14 (UZA II)
1090 Wien

barbara.zdrazil@univie.ac.at