Targeting Solute Carrier Transporters through Functional Mapping. @LaineElodie and I provide a perspective and a general call to create a systematic roadmap for characterizing the SLC superfamily, in the context of drug discovery, structure and function. https://t.co/EX7MFvcuTZ

— Claire Colas (@ColasClaire) November 21, 2020 on Twitter

Targeting Solute Carrier Transporters through Functional Mapping

Claire Colas, Elodie Laine, Trends in Pharmacological Sciences, 2020,
DOI: https://doi.org/10.1016/j.tips.2020.11.005

Abstract

Solute carrier (SLC) transporters are emerging drug targets. Identifying the molecular determinants responsible for their specific and selective transport activities and describing key interactions with their ligands are crucial steps towards the design of potential new drugs. A general functional mapping across more than 400 human SLC transporters would pave the way to the rational and systematic design of molecules modulating cellular transport.

Acknowledgments

This work acknowledges funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No. 777372 (‘RESOLUTE’). This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation program and EFPIA.

Rights and permissions

This is an open access article distributed under the terms of the Creative Commons CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

solute carriers; protein structure; protein evolution; functional mapping