Vienna LiverTox Workspace

Transporters expressed in the liver play a major role in drug pharmacokinetics and are key for maintaining bile flow. Inhibition of these transporters may lead to liver toxicity and drug-drug interactions. Predicting substrate- and inhibition profiles of small molecules towards these transporters may help medicinal chemists to prioritize compounds in an early phase of the drug development process and guide toxicologists in the safety assessment of candidate compounds.

The Vienna LiverTox Workspace allows computing probabilities for a compound to be a substrate or an inhibitor of a considerable number of liver transporters as well as its risk of causing hyperbilirubinemia, cholestasis, and drug-induced liver injury. It uses eTOXlab as core application and is available as a small web application free of charge for non-commercial use. We are grateful for any comments and suggestions.

The computational models are partly based on data derived from the Open PHACTS Discovery Platform and build on the experience we gained in the eTOX project and in SFB35. If you are interested in getting access to the broad panel of models which have been developed in eTOX, please contact gerhard.f.ecker@univie.ac.at.

 

 

Screenshot of the Prediction Page of Vienna LiverTox