Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

Authors/others:Smith, Dennis; Artursson, Per (Uppsala University); Avdeef, Alex; Di, Li (Pfizer Inc); Ecker, Gerhard F.; Faller, Bernard (Novartis Inst Biomed Res, Novartis, Novartis Switzerland, WSJ 350 3 04); Houston, J. Brian (University of Manchester); Kansy, Manfred (F Hoffmann La Roche, Roche Holding, Roche Holding Switzerland, Nonclin Safety Dept); Kerns, Edward H. (NIH, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH) - USA, Natl Ctr Adv Translat Sci); Kramer, Stefanie D. (Eidgenössische Technische Hochschule Zürich); Lennernaes, Hans (Uppsala University); van de Waterbeemd, Han; Sugano, Kiyohiko (Pfizer Ltd); Testa, Bernard (Université de Lausanne)
Language:English
Number of pages:12
Date of publication:2.6.2014
Journal title:Molecular Pharmaceutics
Volume:11
Number:6
Pages:1727-1738
Peer reviewed:true
Links:
Digital Object Identifier (DOI):http://dx.doi.org/10.1021/mp400713v
Publication Type:Review
Portal:https://ucris.univie.ac.at/portal/en/publications/passive-lipoidal-diffusion-and-carriermediated-cell-uptake-are-both-important-mechanisms-of-membrane-permeation-in-drug-disposition(384cf435-3506-49d1-9b87-1f5d86579a57).html