Publications, Patents, Books and Book Chapters


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184 Results
Reibitzer, S, Annibali, D, Eder, M, Kopp, S, Langer, T, Chiba, P, Ecker, G & Noe, C 2003, 'In silico screening with benzofurane- and benzopyrane-type MDR-modulators' Il Farmaco, vol 58, no. 3, pp. 185-191. DOI: 10.1016/S0014-827X(03)00021-1

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Ecker, G 2002, 'Troxacitabine (Shire Pharmaceuticals).' Current Opinion in Investigational Drugs, vol 3, no. 10, pp. 1533-1538.

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Bauer, R, Lauer, R, Linz, B, Pittner, F, Peschek, G, Ecker, G, Friedl, P & Noe, C 2002, 'An in vitro model for blood brain barrier permeation' Scientia Pharmaceutica, vol 70, no. 4, pp. 317-324.

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Chiba, P, Erker, T, Galanski, M & Ecker, G 2002, 'Synthesis and multidrug-resistance modulating activity of a series of thienothiazines' Archiv der Pharmazie, vol 335, no. 5, pp. 223-228.

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Ecker, G, Csaszar, E, Plagens, B, Holzer, W, Ernst, W & Chiba, P 2002, 'Identification of ligand-binding regions of P-glycoprotein by activated-pharmacophore photoaffinity labeling and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry' Molecular Pharmacology, vol 61, no. 3, pp. 637-648. DOI: 10.1124/mol.61.3.637

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Klein, C, Kaiser, D, Kopp, S, Chiba, P & Ecker, G 2002, 'Similarity based SAR (SIBAR) as tool for early ADME profiling' Journal of Computer-Aided Molecular Design, vol 16, no. 11, pp. 785-793. DOI: 10.1023/A:1023828527638

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Wailzer, B, Klocker, J, Buchbauer, G, Ecker, G & Wolschann, KP 2001, 'Prediction of the aroma quality and the threshold values of some pyrazines using artificial neural networks' Journal of Medicinal Chemistry, vol 44, no. 17, pp. 2805-2813.

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Ecker, G, Kalchhauser, H, Lawtrakul, L & Wolschann, KP 2001, 'Levcromakalim Revisited: NMR Spectroscopic and Theoretical Investigations' Monatshefte für Chemie: an international journal of chemistry, vol 132, no. 3, pp. 373-386.

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Ecker, G & Chiba, P 2001, Design and development of propafenone-type inhibitors of drug efflux pumps. in Unknown host publication title. Unknown publisher, pp. 121-137.

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Kaiser, D, Hoffer, C, Chiba, P, Schaper, K-J & Ecker, G 2000, 'Artificial neural networks in drug design II: Influence of learning rate and momentum factor on the predictive ability' Scientia Pharmaceutica, vol 68, no. 1, pp. 57-64.

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Annibali, D, Ecker, G, Fleischhacker, W, Helml, T, Holzer, W & Noe, C 2000, 'A method for the synthesis of 2,3-disubstituted 2,3-dihydrobenzofurans' Monatshefte für Chemie: an international journal of chemistry, vol 131, no. 4, pp. 375-382. DOI: 10.1007/s007060050318

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Buchstaller, H-P, Siebert, CD, Lyssy, RH, Ecker, G, Krug, M, Berger, M, Gottschlich, R & Noe, C 2000, 'Thieno (2,3-b) pyridinones as Antagonists on the Glycine Site of the N-methyl-D-asparatate Receptor-Binding Studies, Molecular Modeling and Structure-Activity-Relationships' Scientia Pharmaceutica, no. 68, pp. 3-14.

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Ecker, G 1999, 'Patent focus on agents for tumour therapy: May - October 1999' Expert Opinion on Therapeutic Patents: authoritative analysis of patenting trends, vol 9, pp. 1627-1639.

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Ecker, G, Schmid, D & Chiba, P 1999, 'The importance of a nitrogen atom in modulators of multidrug resistance' Molecular Pharmacology, vol 56, pp. 791-796.

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Ecker, G, Chiba, P, Hitzler, M & Schmid, D 1999, 'Structure-activity relationship studies of propafenone analogs based on P-glycoprotein ATPase activity measurements' Biochemical Pharmacology, vol 58, pp. 1447-1456.

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Kratzel, M, Hiessböck, R, Ecker, G, Chiba, P & Hitzler, M 1999, 'Synthesis and in vitro multidrug resistance modulating activity of a series of dihydrobenzopyrans and tetrahydroquinolines' Journal of Medicinal Chemistry, vol 42, pp. 1921-1926.

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Ecker, G, Fleischhacker, W, Schaper, K-J & Chiba, P 1999, 'Artificial neural networks as versatile tools for prediction of MDR-modulatory activity' Advances in Experimental Medicine and Biology, vol 457, pp. 95-105.

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Ecker, G, Chiba, P & Hitzler, M 1998, 'Studies on propafenone-type modulators of mutlidrug resistance VIII: Synthesis and pharmacological activity of indanone analogues' Scientia Pharmaceutica, vol 66, pp. 147-168.

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Ecker, G & Urban, E 1998, 'Studies on the absolute configuration and the enantiomeric purity of the antibiotic heptelidic acid' Scientia Pharmaceutica, vol 66, pp. 199-204.

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Ecker, G, Hitzler, M & Chiba, P 1998, 'Studies on propafenone-type modulators of multidrug resistance VI: synthesis and pharmacological activity of compounds with varied spacer length between the central aromatic ring and the nitrogen atom' Il Farmaco, vol 53, pp. 357-364.

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Holzer, W, Ecker, G, Hitzler, M & Chiba, P 1998, 'Substituted 4-acylpyrazoles and -pyrazolones: synthesis and MDR-modulating activity' Journal of Medicinal Chemistry, vol 41, pp. 4001-4011.

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Ecker, G, Chiba, P, Schaper, K-J & Hitzler, M 1998, 'A combined Hansch/Free-Wilson approach as predictive tool in QSAR studies on propafenone-type modulators of multidrug resistance' Archiv der Pharmazie, vol 331, pp. 233-240.

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Ecker, G, Hitzler, M & Chiba, P 1998, 'Synthesis and pharmacological activity of the stereoisomers of GP-88, a propafenone-type modulator of multidrug resistance' Bioorganic & Medicinal Chemistry Letters, vol 8, pp. 829-832.

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Fleischhacker, W, Ecker, G & Wolschann, KP 1998, 'A quantum chemical study of levcromakalim' Monatshefte für Chemie: an international journal of chemistry, vol 129, pp. 633-642.

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Jäger, W & Ecker, G 1998, 'Metabolism of the new MDR-modifier AM05 by human liver microsomes' Scientia Pharmaceutica, vol 66, pp. 159-168.

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Ecker, G & Chiba, P 1997, 'Recent developments in overcoming tumour cell multi-drug resistance' Expert Opinion on Therapeutic Patents: authoritative analysis of patenting trends, vol 7, pp. 589-599.

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Ecker, G 1997, 'Sodium channel modulators in preclinical and early clinical development' Ion Channel Modulators, vol 2, pp. 584-591.

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Fleischhacker, W, Noe, C & Ecker, G 1997, 'Improved Synthesis of the Enantiomers of Propafenone Using chiral Building Blocks' Monatshefte für Chemie: an international journal of chemistry, no. 128, pp. 53-59.

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Jäger, W, Ecker, G, Hitzler, M & Chiba, P 1997, 'Studies on propafenone-type modulators of multidrug resistance IV: synthesis and pharmacologic activity of 5-benzyloxy derivatives' Archiv der Pharmazie, vol 330, pp. 343-347.

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Ecker, G, Schaper, K-J & Chiba, P 1997, 'Estimation of chemosensitising activity of modulators of multidrug resistance via combined simultaneous analysis of sigmoidal dose-response curves' Journal of Pharmacy and Pharmacology : JPP; an international journal of pharmaceutical science, vol 49, pp. 305-309.

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Ecker, G, Tumova, I, Racanska, E, Svec, P, Otrusnik, R & Csöllei, J 1997, 'Pharmacological-toxicological evaluation of some newly synthesised analogues of propafenone' Ceska a Slovenska Farmacie, vol 46, pp. 133-136.

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Chiba, P, Hitzler, M & Ecker, G 1997, 'Studies on propafenone-type modulators of multidrug resistance III: Variations on the nitrogen' QSAR & Combinatorial Science, vol 16, no. 5, pp. 361-366. DOI: 10.1002/qsar.19970160502

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Heistracher, P, Lemmens, R, Fleischhacker, W, Ecker, G & Noe, C 1992, Pharmakologisch aktive in Position 3 substituierte alpha-Aminomethyl-2-benzofuranmethanole, Patent No. PCT WO 9217464.

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Ecker, G, Fleischhacker, W & Noe, C 1989, Verfahren zur Herstellung enantiomerenreiner carbonylsubstituierter Aryloxypropanolamine, Patent No. Österr.Patent vom 31.1.1989.

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