Mag. Dr. Lars Richter
Schuetz, DA, de Witte, WEA, Wong, YC, Knasmueller, B, Richter, L, Kokh, DB, Sadiq, SK, Bosma, R, Nederpelt, I, Heitman, LH, Segala, E, Amaral, M, Guo, D, Andres, D, Georgi, V, Stoddart, LA, Hill, S, Cooke, RM, De Graaf, C, Leurs, R, Frech, M, Wade, RC, de Lange, ECM, IJzerman, AP, Müller-Fahrnow, A & Ecker, GF 2017, 'Kinetics for Drug Discovery: an industry-driven effort to target drug residence time' Drug Discovery Today. DOI: 10.1016/j.drudis.2017.02.002
Richter, L & Ecker, GF 2015, 'Medicinal chemistry in the era of big data' Drug Discovery Today: Technologies, Bd 14, S. 37-41. DOI: 10.1016/j.ddtec.2015.06.001
Ratnam, J, Zdrazil, B, Digles, D, Cuadrado-Rodriguez, E, Neefs, J-M, Tipney, H, Siebes, R, Waagmeester, A, Bradley, G, Chau, CH, Richter, L, Brea, J, Evelo, CT, Jacoby, E, Senger, S, Loza, MI, Ecker, GF & Chichester, C 2014, 'The Application of the Open Pharmacological Concepts Triple Store (Open PHACTS) to Support Drug Discovery Research' PLoS ONE, Bd 9, Nr. 12, S. e115460. DOI: 10.1371/journal.pone.0115460
Goldmann, D, Montanari, F, Richter, L, Zdrazil, B & Ecker, GF 2014, 'Exploiting open data: a new era in pharmacoinformatics' Future Medicinal Chemistry, Bd 6, Nr. 5, S. 503-14. DOI: 10.4155/fmc.14.13
Baur, R, Kielar, M, Richter, L, Ernst, M, Ecker, GF & Sigel, E 2013, 'Molecular analysis of the site for 2-arachidonylglycerol (2-AG) on the β₂ subunit of GABA(A) receptors' Journal of Neurochemistry, Bd 126, Nr. 1, S. 29-36. DOI: 10.1111/jnc.12270
Schiesaro, A, Richter, L & Ecker, GF 2013, 'How to solve the problems of docking into a symmetric binding site: the example of the HERG channel' Scientia Pharmaceutica, Bd 81, Nr. 3, S. 677-82. DOI: 10.3797/scipharm.1307-01
Richter, L, de Graaf, C, Sieghart, W, Varagic, Z, Moerzinger, M, de Esch, IJP, Ecker, GF & Ernst, M 2012, 'Diazepam-bound GABA(A) receptor models identify new benzodiazepine binding-site ligands' Nature Chemical Biology, Bd 8, Nr. 5, S. 455-464. DOI: 10.1038/NCHEMBIO.917
Richter, L, Weissensteiner, R, Klepsch, F & Ecker, G 2011, 'Experimental data guided ligand docking: Combining ligand- and structure-based design approaches' Unknown Journal.
Richter, L, Ernst, M, Sieghart, W & Ecker, G 2010, 'Identification of binding modes of benzodiazepine binding site ligands by a combined docking-pharmacophore modeling approach.' Drugs of the Future, Bd 35, S. 173-173.
Baur, R, Lüscher, BP, Richter, L & Sigel, E 2010, 'A residue close to alpha(1) loop F disrupts modulation of GABA(A) receptors by benzodiazepines while their binding is maintained' Journal of Neurochemistry, Bd 115, Nr. 6, S. 1478-1485. DOI: 10.1111/j.1471-4159.2010.07052.x
Richter, L, Ernst, M, Sieghart, W & Ecker, G 2010, 'Identification of binding modes of benzodiazepine binding site ligands by a combined docking-pharmacophore modeling approach.' XXIst International Symposium of Medicinal Chemistry, Brüssel, Belgien, 5/09/10 - 9/09/10,.
Clayton, T, Ernst, M, Richter, L, Sanker, S, DeLorey, TM, Sieghart, W, Furtmüller, R, Ecker, G & Cook, JM 2009, 'Synthesis of subtype selective ligands for α5 containing GABAA/BZ receptors to treat memory deficits' Chemical Abstracts.
Richter, L, Ernst, M, Sieghart, W & Ecker, G 2009, 'Using multiple approaches in docking pose evaluation – application to the GABA-A receptor' 21. Wissenschaftliche Tagung der Österreichischen Pharmazeutischen Gesellschaft, Wien, Österreich, 16/04/09 - 18/04/09,.
Clayton, T, Ernst, M, Richter, L, Sanker, S, DeLorey, TM, Sieghart, W, Furtmüller, R, Ecker, G & Cook, JM 2009, 'Synthesis of subtype selective ligands for α5 containing GABAA/BZ receptors to treat memory deficits' 238th American Chemical Society National Meeting & Exposition, Washington DC, USA / Vereinigte Staaten, 16/08/09 - 20/08/09,.
Richter, L, Ernst, M, Sieghart, W & Ecker, G 2009, 'Combining multiple approaches in pose evaluation - application to the GABA-A receptor' 7th European Workshop in Drug Design, Siena, Italien, 24/05/09 - 30/05/09,.
Schiesaro, A, Richter, L, Windisch, A, Timin, E, Hering, S & Ecker, G 2009, 'Docking into symmetric binding sites: problems and solutions exemplified on the hERG potassium channel' 21. Wissenschaftliche Tagung der Österreichischen Pharmazeutischen Gesellschaft, Wien, Österreich, 16/04/09 - 18/04/09,.
Ecker, G, Richter, L, Ernst, M, Sigel, E & Sieghart, W 2008, 'Experimental data guided ligand docking - a tool for elucidating the binding mode of benzodiazepines' XXth International Symposium on Medicinal Chemistry (EFMC-ISMC 2008), Wien, Österreich, 31/08/08 - 4/09/08,.
Ecker, G, Ecker, G, Richter, L, Sieghart, W, Ernst, M & Sigel, E 2007, 'Ranking ligand docking poses by geometric scores_ application to the GABA-A receptor' Farmacevtski vestnik: strokovno glasilo slovenske farmacije, Bd 58, Nr. Posebna izdaja, S. 173-173.
Ecker, G, Richter, L, Clayton, T, Chen, JL, Cromer, BA, Morton, CJ, Ng, H, Cook, JM, Helmstetter, FJ, Sieghart, W, Ernst, M, Furtmüller, R, Parker, MW & Kaczorowski, CC 2007, 'An updated unified pharmacophore model of the benzodiazepine binding site on gamma-aminobutyric acid receptors: correlation with comparative models' Current Medicinal Chemistry, S. 2755-2775.

Department für Pharmazeutische Chemie

Althanstraße 14 (UZA II)
1090 Wien
Room: 2E407

lars.richter@univie.ac.at