Mag. Dr. Lars Richter
Jain, S, Grandits, M, Richter, L & Ecker, GF 2017, 'Structure based classification for bile salt export pump (BSEP) inhibitors using comparative structural modeling of human BSEP' Journal of Computer-Aided Molecular Design, Bd 31, Nr. 6, S. 507-521. DOI: 10.1007/s10822-017-0021-x
Schuetz, DA, de Witte, WEA, Wong, YC, Knasmueller, B, Richter, L, Kokh, DB, Sadiq, SK, Bosma, R, Nederpelt, I, Heitman, LH, Segala, E, Amaral, M, Guo, D, Andres, D, Georgi, V, Stoddart, LA, Hill, S, Cooke, RM, De Graaf, C, Leurs, R, Frech, M, Wade, RC, de Lange, ECM, IJzerman, AP, Müller-Fahrnow, A & Ecker, GF 2017, 'Kinetics for Drug Discovery: an industry-driven effort to target drug residence time' Drug Discovery Today. DOI: 10.1016/j.drudis.2017.02.002
Richter, L & Ecker, GF 2015, 'Medicinal chemistry in the era of big data' Drug Discovery Today: Technologies, Bd 14, S. 37-41. DOI: 10.1016/j.ddtec.2015.06.001
Ratnam, J, Zdrazil, B, Digles, D, Cuadrado-Rodriguez, E, Neefs, J-M, Tipney, H, Siebes, R, Waagmeester, A, Bradley, G, Chau, CH, Richter, L, Brea, J, Evelo, CT, Jacoby, E, Senger, S, Loza, MI, Ecker, GF & Chichester, C 2014, 'The Application of the Open Pharmacological Concepts Triple Store (Open PHACTS) to Support Drug Discovery Research' PLoS ONE, Bd 9, Nr. 12, S. e115460. DOI: 10.1371/journal.pone.0115460
Goldmann, D, Montanari, F, Richter, L, Zdrazil, B & Ecker, GF 2014, 'Exploiting open data: a new era in pharmacoinformatics' Future Medicinal Chemistry, Bd 6, Nr. 5, S. 503-14. DOI: 10.4155/fmc.14.13
Baur, R, Kielar, M, Richter, L, Ernst, M, Ecker, GF & Sigel, E 2013, 'Molecular analysis of the site for 2-arachidonylglycerol (2-AG) on the β₂ subunit of GABA(A) receptors' Journal of Neurochemistry, Bd 126, Nr. 1, S. 29-36. DOI: 10.1111/jnc.12270
Schiesaro, A, Richter, L & Ecker, GF 2013, 'How to solve the problems of docking into a symmetric binding site: the example of the HERG channel' Scientia Pharmaceutica, Bd 81, Nr. 3, S. 677-82. DOI: 10.3797/scipharm.1307-01
Richter, L, de Graaf, C, Sieghart, W, Varagic, Z, Moerzinger, M, de Esch, IJP, Ecker, GF & Ernst, M 2012, 'Diazepam-bound GABA(A) receptor models identify new benzodiazepine binding-site ligands' Nature Chemical Biology, Bd 8, Nr. 5, S. 455-464. DOI: 10.1038/NCHEMBIO.917
Richter, L, Weissensteiner, R, Klepsch, F & Ecker, G 2011, 'Experimental data guided ligand docking: Combining ligand- and structure-based design approaches' Unknown Journal.
Richter, L, Ernst, M, Sieghart, W & Ecker, G 2010, 'Identification of binding modes of benzodiazepine binding site ligands by a combined docking-pharmacophore modeling approach.' Drugs of the Future, Bd 35, S. 173-173.
Baur, R, Lüscher, BP, Richter, L & Sigel, E 2010, 'A residue close to alpha(1) loop F disrupts modulation of GABA(A) receptors by benzodiazepines while their binding is maintained' Journal of Neurochemistry, Bd 115, Nr. 6, S. 1478-1485. DOI: 10.1111/j.1471-4159.2010.07052.x
Richter, L, Ernst, M, Sieghart, W & Ecker, G 2010, 'Identification of binding modes of benzodiazepine binding site ligands by a combined docking-pharmacophore modeling approach.' XXIst International Symposium of Medicinal Chemistry, Brüssel, Belgien, 5/09/10 - 9/09/10,.
Clayton, T, Ernst, M, Richter, L, Sanker, S, DeLorey, TM, Sieghart, W, Furtmüller, R, Ecker, G & Cook, JM 2009, 'Synthesis of subtype selective ligands for α5 containing GABAA/BZ receptors to treat memory deficits' Chemical Abstracts.
Richter, L, Ernst, M, Sieghart, W & Ecker, G 2009, 'Using multiple approaches in docking pose evaluation – application to the GABA-A receptor' 21. Wissenschaftliche Tagung der Österreichischen Pharmazeutischen Gesellschaft, Wien, Österreich, 16/04/09 - 18/04/09,.
Clayton, T, Ernst, M, Richter, L, Sanker, S, DeLorey, TM, Sieghart, W, Furtmüller, R, Ecker, G & Cook, JM 2009, 'Synthesis of subtype selective ligands for α5 containing GABAA/BZ receptors to treat memory deficits' 238th American Chemical Society National Meeting & Exposition, Washington DC, USA / Vereinigte Staaten, 16/08/09 - 20/08/09,.
Richter, L, Ernst, M, Sieghart, W & Ecker, G 2009, 'Combining multiple approaches in pose evaluation - application to the GABA-A receptor' 7th European Workshop in Drug Design, Siena, Italien, 24/05/09 - 30/05/09,.
Schiesaro, A, Richter, L, Windisch, A, Timin, E, Hering, S & Ecker, G 2009, 'Docking into symmetric binding sites: problems and solutions exemplified on the hERG potassium channel' 21. Wissenschaftliche Tagung der Österreichischen Pharmazeutischen Gesellschaft, Wien, Österreich, 16/04/09 - 18/04/09,.
Ecker, G, Richter, L, Ernst, M, Sigel, E & Sieghart, W 2008, 'Experimental data guided ligand docking - a tool for elucidating the binding mode of benzodiazepines' XXth International Symposium on Medicinal Chemistry (EFMC-ISMC 2008), Wien, Österreich, 31/08/08 - 4/09/08,.
Ecker, G, Ecker, G, Richter, L, Sieghart, W, Ernst, M & Sigel, E 2007, 'Ranking ligand docking poses by geometric scores_ application to the GABA-A receptor' Farmacevtski vestnik: strokovno glasilo slovenske farmacije, Bd 58, Nr. Posebna izdaja, S. 173-173.
Ecker, G, Richter, L, Clayton, T, Chen, JL, Cromer, BA, Morton, CJ, Ng, H, Cook, JM, Helmstetter, FJ, Sieghart, W, Ernst, M, Furtmüller, R, Parker, MW & Kaczorowski, CC 2007, 'An updated unified pharmacophore model of the benzodiazepine binding site on gamma-aminobutyric acid receptors: correlation with comparative models' Current Medicinal Chemistry, S. 2755-2775.

Department für Pharmazeutische Chemie

Althanstraße 14 (UZA II)
1090 Wien
Room: 2E407

lars.richter@univie.ac.at