Mag. Dr. Lars Richter
T: +43-1-4277-55113


Schuetz, DA, de Witte, WEA, Wong, YC, Knasmueller, B, Richter, L, Kokh, DB, Sadiq, SK, Bosma, R, Nederpelt, I, Heitman, LH, Segala, E, Amaral, M, Guo, D, Andres, D, Georgi, V, Stoddart, LA, Hill, S, Cooke, RM, De Graaf, C, Leurs, R, Frech, M, Wade, RC, de Lange, ECM, IJzerman, AP, Müller-Fahrnow, A & Ecker, GF 2017, 'Kinetics for Drug Discovery: an industry-driven effort to target drug residence time' Drug Discovery Today, vol 22, no. 6, pp. 896-911. DOI: 10.1016/j.drudis.2017.02.002



Ratnam, J, Zdrazil, B, Digles, D, Cuadrado-Rodriguez, E, Neefs, J-M, Tipney, H, Siebes, R, Waagmeester, A, Bradley, G, Chau, CH, Richter, L, Brea, J, Evelo, CT, Jacoby, E, Senger, S, Loza, MI, Ecker, GF & Chichester, C 2014, 'The Application of the Open Pharmacological Concepts Triple Store (Open PHACTS) to Support Drug Discovery Research' PLOS ONE, vol 9, no. 12, pp. e115460. DOI: 10.1371/journal.pone.0115460




Richter, L, de Graaf, C, Sieghart, W, Varagic, Z, Moerzinger, M, de Esch, IJP, Ecker, GF & Ernst, M 2012, 'Diazepam-bound GABA(A) receptor models identify new benzodiazepine binding-site ligands' Nature Chemical Biology, vol 8, no. 5, pp. 455-464. DOI: 10.1038/NCHEMBIO.917




Richter, L, Ernst, M, Sieghart, W & Ecker, G 2010, 'Identification of binding modes of benzodiazepine binding site ligands by a combined docking-pharmacophore modeling approach.' XXIst International Symposium of Medicinal Chemistry, Brüssel, Belgium, 5/09/10 - 9/09/10, .

Richter, L, Ernst, M, Sieghart, W & Ecker, G 2009, 'Combining multiple approaches in pose evaluation - application to the GABA-A receptor' 7th European Workshop in Drug Design, Siena, Italy, 24/05/09 - 30/05/09, .

Schiesaro, A, Richter, L, Windisch, A, Timin, E, Hering, S & Ecker, G 2009, 'Docking into symmetric binding sites: problems and solutions exemplified on the hERG potassium channel' 21. Wissenschaftliche Tagung der Österreichischen Pharmazeutischen Gesellschaft, Wien, Austria, 16/04/09 - 18/04/09, .

Clayton, T, Ernst, M, Richter, L, Sanker, S, DeLorey, TM, Sieghart, W, Furtmüller, R, Ecker, G & Cook, JM 2009, 'Synthesis of subtype selective ligands for α5 containing GABAA/BZ receptors to treat memory deficits' Chemical Abstracts.

Clayton, T, Ernst, M, Richter, L, Sanker, S, DeLorey, TM, Sieghart, W, Furtmüller, R, Ecker, G & Cook, JM 2009, 'Synthesis of subtype selective ligands for α5 containing GABAA/BZ receptors to treat memory deficits' 238th American Chemical Society National Meeting & Exposition, Washington DC, United States, 16/08/09 - 20/08/09, .

Richter, L, Ernst, M, Sieghart, W & Ecker, G 2009, 'Using multiple approaches in docking pose evaluation – application to the GABA-A receptor' 21. Wissenschaftliche Tagung der Österreichischen Pharmazeutischen Gesellschaft, Wien, Austria, 16/04/09 - 18/04/09, .

Ecker, G, Richter, L, Ernst, M, Sigel, E & Sieghart, W 2008, 'Experimental data guided ligand docking - a tool for elucidating the binding mode of benzodiazepines' XXth International Symposium on Medicinal Chemistry (EFMC-ISMC 2008), Wien, Austria, 31/08/08 - 4/09/08, .

Ecker, G, Richter, L, Clayton, T, Chen, JL, Cromer, BA, Morton, CJ, Ng, H, Cook, JM, Helmstetter, FJ, Sieghart, W, Ernst, M, Furtmüller, R, Parker, MW & Kaczorowski, CC 2007, 'An updated unified pharmacophore model of the benzodiazepine binding site on gamma-aminobutyric acid receptors: correlation with comparative models' Current Medicinal Chemistry, pp. 2755-2775.


Optimizing Ligands for Promiscuous Targets - A Case Study for P-glycoprotein Inhibitors

Richter, L. (Contributor)
26 Sep 2008

Activity: OtherTalk or oral contribution


Department für Pharmazeutische Chemie

Althanstraße 14 (UZA II)
1090 Wien
Room: 2E407

T: +43-1-4277-55113

lars.richter@univie.ac.at