Univ.-Prof. Dr. Gerhard Ecker

Place of Birth: Seitenstetten (Lower Austria)

Nationality: Austria


Bibliographic Sketch

Gerhard Ecker is Full Professor for Pharmacoinformatics and Head of the Pharmacoinformatics Research Group at the Department of Medicinal Chemistry, University of Vienna. He also coordinates the research focus “Computational Life Sciences” of the Faculty of Life Sciences. Gerhard received his doctorate in natural sciences from the University of Vienna and performed his post-doctoral training at the group of J. Seydel in Borstel (Germany). He has published more than 100 articles related to SAR and QSAR studies on P-glycoprotein and other transporters and antitargets. His main scientific interests include pharmacoinformatic approaches to target drug efflux pumps, in silico screening methods for promiscuous targets and antitargets, and non-linear methods in drug design. Gerhard was vice-chair of the Senate of the University of Vienna 2006 – 2009, he is currently vice-president of the Austrian Pharmaceutical Society and President of the European Federation for Medicinal Chemistry. From Oct 1st 2009 on he holds a position as full professor for pharmacoinformatics at the University of Vienna.


Education and Career

1981-1986Study of Pharmacy, University of Vienna

Ph.D. under supervision of Prof. Fleischhacker and Prof. Noe: "Synthesis of the enantiomers of propafenone and benzofurane analogous compounds"
Graduated to Dr. rer. nat., University of Vienna

1995Post-doc stay in the group of Prof. Seydel, Research Center, Borstel, Germany
1998Habilitation (venia docendi; Assoc. Prof.) for Pharmaceutical Chemistry, University of Vienna: „Structure-Activity Relationship Studies on Modulators of Multidrug Resis-tance“
2004 -Coordinator of the Research Focus „Computational Life Sciences“ at the Faculty of Life Sciences, University of Vienna
2005-2008Head of the Emerging Field Pharmacoinformatics, Department of Medicinal Chemis-try, University of Vienna
2008Offer from the University of Tübingen for the appointment as full professor (W3) for Medicinal Chemistry - Drug Design, declined 
Oct 2009Appointment as full professor for Pharmacoinformatics, University of Vienna


University Organization

2003-Member of the Senate of the University of Vienna, Vice Chair since June 2006
2004-2006   Mentor in the mu:v Mentoring University Vienna Program for the promotion of Women in Sciences



1997  HERBA-Award for excellent pharmaceutical research
2002Prize of the City of Vienna for Achievements in Sciences (Förderpreis der Stadt Wien für die Wissenschaften)



1996-   Member of the Executive Committee of the Austrian Pharmaceutical Society, Vice President since Jan 2006
2000-Member of the Council of the European Federation for Medicinal Chemistry
2003-   Member of the Executive Committee of the European Federation for Medicinal Chemistry, Secretary 2003 – 2007, President-elect 2008
2009-   President of the European Federation for Medicinal Chemistry


Editorial Boards

1997-   Member of the Editorial Board of Expert Opinions on Therapeutic Patents, Section En-docrine and Oncologic.
2003-Member of the Editorial Advisory Board of Current Computer-Aided Drug Design
2004-Member of the Editorial Advisory Board of Medicinal Chemistry
2007-2008   Editor of MedChemWatch, the e-newsletter of the European Federation for Medicinal Chemistry
2009-Member of the Editorial Advisory Board of Future Medicinal Chemistry
2010-Editor of Molecular Informatics


Congresses, Symposia

2001Summer School on Drug Design, Vienna; Organiser
2005   Joint Meeting on Medicinal Chemistry, Vienna; co-chair
2006International Symposium on Medicinal Chemistry, Istanbul; Member International Organising Committee
2008International Symposium on Medicinal Chemistry, Vienna; Member International Organising Committee
2009Advances in Synthetic and Medicinal Chemistry, Kiev; Co-chair International Organising Committee
2010International Symposium on Medicinal Chemistry, Brussels; Member International Organising Committee


Research Activities

at present 102 full papers, > 200 conference contributions and 98 invited lectures

  • Modulation of multidrug resistance via inhibition of toxin efflux pumps
  • Artificial Neural Networks for lead identification and drug design
  • Chemical similarity as tool for rational drug design
  • Early ADME Profiling and in silico screening of polyspecific targets
  • Structure-based design approaches for polyspecific proteins
  • Homology modelling and molecular dynamics simulations of membrane-bound proteins



  • Mathematics and Statistics for Pharmacists
  • Biophysical Pharmaceutical Chemistry
  • Analysis of Structure-Activity Relationships
  • Bioinformatics and Protein Modelling for Pharmacists
  • Molecular Modelling for Pharmacists - Exercises
  • Drug Resistance – Mechanisms and Solutions
  • Rational Drug Design (Seminar)
  • Pharmacoinformatics (Seminar)
  • Computational Life Sciences (Seminar)
  • Laboratory Course – Drug Analysis and –development (including in silico methods)

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